Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)

Fan Zhang; Depeng Li; Yiwen Yang; Hanwen Zhang; Jiahua Zhu; Jiadai Liu; Xianyong Bu; Erchao Li; Jianguang Qin; Na Yu; Liqiao Chen; Xiaodan Wang

doi:10.1016/j.scitotenv.2021.152099

Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)

Fan Zhang, Depeng Li, Yiwen Yang, Hanwen Zhang, Jiahua Zhu, Jiadai Liu, Xianyong Bu, Erchao Li, Jianguang Qin, Na Yu, Liqiao Chen, Xiaodan Wang

College of Science and Engineering

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Microplastics (MPs) coexist with other pollutants (such as heavy metals) in water, adversely impacting aquatic organisms, which might cause unpredictable ecological risks. This study aims to evaluate the effect of copper (Cu²⁺) and polystyrene microplastics (PS-MPs) on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia. Cu²⁺ and PS-MPs co-exposure enhanced Cu²⁺ bioaccumulation in the liver of fish compared with Cu²⁺-alone exposure. Fish exposed to PS-MPs and Cu²⁺ displayed histopathologic alterations in the liver, intestine and gill. Exposure at low concentrations of Cu²⁺ in the C0 and CP0 groups can improve antioxidant capacity and immune response, while oxidative damage and inflammation existed in the high concentration of Cu²⁺ groups. Intestinal microbiota results showed that the diversity and structure were changed by Cu²⁺ and PS-MPs exposure, and harmful bacterium even increased at high concentration of Cu²⁺ and PS-MPs exposure groups. All in all, PS-MPs aggravate the accumulation of Cu²⁺ and lead to perturbations in biological systems of Nile tilapia.

Original language	English
Article number	152099
Number of pages	12
Journal	Science of The Total Environment
Volume	808
DOIs	https://doi.org/10.1016/j.scitotenv.2021.152099
Publication status	Published - 20 Feb 2022

Bibliographical note

Funding Information:
This work was supported by grants from the National Natural Science Foundation of China (No. 31802311 ), China Postdoctoral Science Foundation ( 2018 M630418 ), the Fundamental Research Funds for the Central Universities , ECNU and China Agriculture Research System-46 (CARS-46).

Publisher Copyright:
© 2021

Keywords

Antioxidant capacity
Copper
Immune response
Intestinal microbiota
Nile tilapia
Polystyrene microplastics

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Zhang, F., Li, D., Yang, Y., Zhang, H., Zhu, J., Liu, J., Bu, X., Li, E., Qin, J., Yu, N., Chen, L., & Wang, X. (2022). Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus). Science of The Total Environment, 808, Article 152099. https://doi.org/10.1016/j.scitotenv.2021.152099

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title = "Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)",

abstract = "Microplastics (MPs) coexist with other pollutants (such as heavy metals) in water, adversely impacting aquatic organisms, which might cause unpredictable ecological risks. This study aims to evaluate the effect of copper (Cu2+) and polystyrene microplastics (PS-MPs) on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia. Cu2+ and PS-MPs co-exposure enhanced Cu2+ bioaccumulation in the liver of fish compared with Cu2+-alone exposure. Fish exposed to PS-MPs and Cu2+ displayed histopathologic alterations in the liver, intestine and gill. Exposure at low concentrations of Cu2+ in the C0 and CP0 groups can improve antioxidant capacity and immune response, while oxidative damage and inflammation existed in the high concentration of Cu2+ groups. Intestinal microbiota results showed that the diversity and structure were changed by Cu2+ and PS-MPs exposure, and harmful bacterium even increased at high concentration of Cu2+ and PS-MPs exposure groups. All in all, PS-MPs aggravate the accumulation of Cu2+ and lead to perturbations in biological systems of Nile tilapia.",

keywords = "Antioxidant capacity, Copper, Immune response, Intestinal microbiota, Nile tilapia, Polystyrene microplastics",

author = "Fan Zhang and Depeng Li and Yiwen Yang and Hanwen Zhang and Jiahua Zhu and Jiadai Liu and Xianyong Bu and Erchao Li and Jianguang Qin and Na Yu and Liqiao Chen and Xiaodan Wang",

note = "Funding Information: This work was supported by grants from the National Natural Science Foundation of China (No. 31802311 ), China Postdoctoral Science Foundation ( 2018 M630418 ), the Fundamental Research Funds for the Central Universities , ECNU and China Agriculture Research System-46 (CARS-46). Publisher Copyright: {\textcopyright} 2021",

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Zhang, F, Li, D, Yang, Y, Zhang, H, Zhu, J, Liu, J, Bu, X, Li, E, Qin, J, Yu, N, Chen, L & Wang, X 2022, 'Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)', Science of The Total Environment, vol. 808, 152099. https://doi.org/10.1016/j.scitotenv.2021.152099

TY - JOUR

T1 - Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)

AU - Zhang, Fan

AU - Li, Depeng

AU - Yang, Yiwen

AU - Zhang, Hanwen

AU - Zhu, Jiahua

AU - Liu, Jiadai

AU - Bu, Xianyong

AU - Li, Erchao

AU - Qin, Jianguang

AU - Yu, Na

AU - Chen, Liqiao

AU - Wang, Xiaodan

N1 - Funding Information: This work was supported by grants from the National Natural Science Foundation of China (No. 31802311 ), China Postdoctoral Science Foundation ( 2018 M630418 ), the Fundamental Research Funds for the Central Universities , ECNU and China Agriculture Research System-46 (CARS-46). Publisher Copyright: © 2021

PY - 2022/2/20

Y1 - 2022/2/20

N2 - Microplastics (MPs) coexist with other pollutants (such as heavy metals) in water, adversely impacting aquatic organisms, which might cause unpredictable ecological risks. This study aims to evaluate the effect of copper (Cu2+) and polystyrene microplastics (PS-MPs) on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia. Cu2+ and PS-MPs co-exposure enhanced Cu2+ bioaccumulation in the liver of fish compared with Cu2+-alone exposure. Fish exposed to PS-MPs and Cu2+ displayed histopathologic alterations in the liver, intestine and gill. Exposure at low concentrations of Cu2+ in the C0 and CP0 groups can improve antioxidant capacity and immune response, while oxidative damage and inflammation existed in the high concentration of Cu2+ groups. Intestinal microbiota results showed that the diversity and structure were changed by Cu2+ and PS-MPs exposure, and harmful bacterium even increased at high concentration of Cu2+ and PS-MPs exposure groups. All in all, PS-MPs aggravate the accumulation of Cu2+ and lead to perturbations in biological systems of Nile tilapia.

AB - Microplastics (MPs) coexist with other pollutants (such as heavy metals) in water, adversely impacting aquatic organisms, which might cause unpredictable ecological risks. This study aims to evaluate the effect of copper (Cu2+) and polystyrene microplastics (PS-MPs) on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia. Cu2+ and PS-MPs co-exposure enhanced Cu2+ bioaccumulation in the liver of fish compared with Cu2+-alone exposure. Fish exposed to PS-MPs and Cu2+ displayed histopathologic alterations in the liver, intestine and gill. Exposure at low concentrations of Cu2+ in the C0 and CP0 groups can improve antioxidant capacity and immune response, while oxidative damage and inflammation existed in the high concentration of Cu2+ groups. Intestinal microbiota results showed that the diversity and structure were changed by Cu2+ and PS-MPs exposure, and harmful bacterium even increased at high concentration of Cu2+ and PS-MPs exposure groups. All in all, PS-MPs aggravate the accumulation of Cu2+ and lead to perturbations in biological systems of Nile tilapia.

KW - Antioxidant capacity

KW - Copper

KW - Immune response

KW - Intestinal microbiota

KW - Nile tilapia

KW - Polystyrene microplastics

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U2 - 10.1016/j.scitotenv.2021.152099

DO - 10.1016/j.scitotenv.2021.152099

M3 - Article

AN - SCOPUS:85120666608

SN - 0048-9697

VL - 808

JO - Science of The Total Environment

JF - Science of The Total Environment

M1 - 152099

ER -

Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)

Abstract

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Keywords

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