Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus)

Fan Zhang, Depeng Li, Yiwen Yang, Hanwen Zhang, Jiahua Zhu, Jiadai Liu, Xianyong Bu, Erchao Li, Jianguang Qin, Na Yu, Liqiao Chen, Xiaodan Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Microplastics (MPs) coexist with other pollutants (such as heavy metals) in water, adversely impacting aquatic organisms, which might cause unpredictable ecological risks. This study aims to evaluate the effect of copper (Cu2+) and polystyrene microplastics (PS-MPs) on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia. Cu2+ and PS-MPs co-exposure enhanced Cu2+ bioaccumulation in the liver of fish compared with Cu2+-alone exposure. Fish exposed to PS-MPs and Cu2+ displayed histopathologic alterations in the liver, intestine and gill. Exposure at low concentrations of Cu2+ in the C0 and CP0 groups can improve antioxidant capacity and immune response, while oxidative damage and inflammation existed in the high concentration of Cu2+ groups. Intestinal microbiota results showed that the diversity and structure were changed by Cu2+ and PS-MPs exposure, and harmful bacterium even increased at high concentration of Cu2+ and PS-MPs exposure groups. All in all, PS-MPs aggravate the accumulation of Cu2+ and lead to perturbations in biological systems of Nile tilapia.

Original languageEnglish
Article number152099
Number of pages12
JournalScience of The Total Environment
Volume808
DOIs
Publication statusPublished - 20 Feb 2022

Bibliographical note

Funding Information:
This work was supported by grants from the National Natural Science Foundation of China (No. 31802311 ), China Postdoctoral Science Foundation ( 2018 M630418 ), the Fundamental Research Funds for the Central Universities , ECNU and China Agriculture Research System-46 (CARS-46).

Publisher Copyright:
© 2021

Keywords

  • Antioxidant capacity
  • Copper
  • Immune response
  • Intestinal microbiota
  • Nile tilapia
  • Polystyrene microplastics

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