Thomas et al. found associations between nicotine replacement therapy use and neuropsychiatric and cardiovascular adverse events using a case–cross‐over study design. This contradicts randomized controlled trials that have found the pharmacotherapies to be safe. Many smokers may have comorbidities or are using medications that may impact upon adverse events. A range of study designs is needed to explore every aspect of pharmacotherapy use and effects.
- Adverse events
- smoking cessation