Comparative study on neuroprotective activities of fucoidans from Fucus vesiculosus and Undaria pinnatifida

Mousa Alghazwi, Scott Smid, Samuel Karpiniec, Wei Zhang

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    This study investigated the neuroprotective activities of five different fucoidan samples with different chemical compositions prepared from Fucus vesiculosus (FE, FF, and S) and Undaria pinnatifida (UE and UF) to determine if they reduced aggregation or cytotoxicity of Aβ 1–42 in neuronal PC-12 cells. Only fucoidans S, UE, and UF showed anti-aggregation effects against Aβ 1–42 , as determined using Thioflavin T (ThT) fluorometric fibrillisation kinetics and transmission electron microscopy (TEM) of fibril morphology. However, all five fucoidan samples reduced the cytotoxicity of both Aβ 1–42 and hydrogen peroxide in neuronal PC-12 cells and demonstrated inhibition of apoptosis induced by Aβ 1–42 . Three fucoidan samples (FF, UE and UF) showed significant activity in enhancing neurite outgrowth. Fucoidan from different seaweed sources and with varying chemical compositions demonstrate a range of neuroprotective activities that may have potential to alter Aβ 1–42 neurotoxicity in Alzheimer's disease.

    Original languageEnglish
    Pages (from-to)255-264
    Number of pages10
    JournalINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
    Volume122
    DOIs
    Publication statusPublished - 1 Feb 2019

    Keywords

    • Alzheimer's disease
    • Amyloid beta
    • Fucoidan
    • Macroalgae
    • Neuroprotective activity
    • Seaweed

    Fingerprint Dive into the research topics of 'Comparative study on neuroprotective activities of fucoidans from Fucus vesiculosus and Undaria pinnatifida'. Together they form a unique fingerprint.

  • Cite this