TY - JOUR
T1 - Comparative study on neuroprotective activities of fucoidans from Fucus vesiculosus and Undaria pinnatifida
AU - Alghazwi, Mousa
AU - Smid, Scott
AU - Karpiniec, Samuel
AU - Zhang, Wei
PY - 2019/2/1
Y1 - 2019/2/1
N2 - This study investigated the neuroprotective activities of five different fucoidan samples with different chemical compositions prepared from Fucus vesiculosus (FE, FF, and S) and Undaria pinnatifida (UE and UF) to determine if they reduced aggregation or cytotoxicity of Aβ 1–42 in neuronal PC-12 cells. Only fucoidans S, UE, and UF showed anti-aggregation effects against Aβ 1–42 , as determined using Thioflavin T (ThT) fluorometric fibrillisation kinetics and transmission electron microscopy (TEM) of fibril morphology. However, all five fucoidan samples reduced the cytotoxicity of both Aβ 1–42 and hydrogen peroxide in neuronal PC-12 cells and demonstrated inhibition of apoptosis induced by Aβ 1–42 . Three fucoidan samples (FF, UE and UF) showed significant activity in enhancing neurite outgrowth. Fucoidan from different seaweed sources and with varying chemical compositions demonstrate a range of neuroprotective activities that may have potential to alter Aβ 1–42 neurotoxicity in Alzheimer's disease.
AB - This study investigated the neuroprotective activities of five different fucoidan samples with different chemical compositions prepared from Fucus vesiculosus (FE, FF, and S) and Undaria pinnatifida (UE and UF) to determine if they reduced aggregation or cytotoxicity of Aβ 1–42 in neuronal PC-12 cells. Only fucoidans S, UE, and UF showed anti-aggregation effects against Aβ 1–42 , as determined using Thioflavin T (ThT) fluorometric fibrillisation kinetics and transmission electron microscopy (TEM) of fibril morphology. However, all five fucoidan samples reduced the cytotoxicity of both Aβ 1–42 and hydrogen peroxide in neuronal PC-12 cells and demonstrated inhibition of apoptosis induced by Aβ 1–42 . Three fucoidan samples (FF, UE and UF) showed significant activity in enhancing neurite outgrowth. Fucoidan from different seaweed sources and with varying chemical compositions demonstrate a range of neuroprotective activities that may have potential to alter Aβ 1–42 neurotoxicity in Alzheimer's disease.
KW - Alzheimer's disease
KW - Amyloid beta
KW - Fucoidan
KW - Macroalgae
KW - Neuroprotective activity
KW - Seaweed
UR - http://www.scopus.com/inward/record.url?scp=85055914352&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2018.10.168
DO - 10.1016/j.ijbiomac.2018.10.168
M3 - Article
C2 - 30401646
AN - SCOPUS:85055914352
SN - 0141-8130
VL - 122
SP - 255
EP - 264
JO - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
JF - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ER -