Abstract
This study compared the efficacy and tolerability of monotherapy with felodipine and enalapril in patients with essential hypertension using a double-blind randomised crossover design. Thirty-five subjects (22 male, 13 female-ages: median 48 years, range 31-69 years) entered the randomised phases of the study and 32 subjects completed the study. Following a 4-week run-in placebo phase, the treatments were felodipine ("Plendil ER" 5-20 mg and enalapril 5-20 mg orally once daily for 8 weeks, each with matching placebos. Dose titration was at 2 and/or 4 weeks in each phase. Number of subjects with each different end-of-phase dose were for felodipine: 5 mg-8, 10 mg-11, 20 mg-13 and enalapril: 5 mg-6, 10 mg-9, 20 mg-17. Predose supine blood pressure (mean SEM) was reduced in both active treatment phases compared wih the run-in phase (159 ±2/101 ± 1), but there was no significant difference in blood pressure between the active phases: felodipine 143±2/90±1 and enalapril 146±2/92±1. The most common adverse effects were for felodipine: headache, flushing, ankle swelling; and for enalapril: cough. Felodipine and enalapril as once daily monotherapy are thus of similar antihypertensive efficacy but with predictably different adverse effect profiles.
Original language | English |
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Pages (from-to) | 53-58 |
Number of pages | 6 |
Journal | Blood Pressure |
Volume | 2 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 1993 |
Externally published | Yes |
Keywords
- Angiotensin-converting enzyme inhibitors
- Calcium channel blockers
- Enalapril
- Felodipine
- Hypertension