Comparison of the performance of different silicon-based SALDI substrates for illicit drug detection

Taryn Guinan; Maurizio Ronci; Roshan Vasani; Hilton Kobus; Nicholas Voelcker

doi:10.1016/j.talanta.2014.09.040

Comparison of the performance of different silicon-based SALDI substrates for illicit drug detection

Taryn Guinan, Maurizio Ronci, Roshan Vasani, Hilton Kobus, Nicholas Voelcker

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) is an emerging technique used for the detection of small molecules (<700 Da) such as illicit drugs. In recent times, this technique has been employed for the detection of illicit drugs in various body fluids including saliva. Three common SALDI techniques, desorption ionization on porous silicon (DIOS), nanostructure-initiator mass spectrometry (NIMS) and nanostructured laser desorption ionization (NALDI^™) are compared for the detection of four drug classes, amphetamines, benzodiazepines, opiates and tropane alkaloids. We focus in our comparison on structural and chemical characteristics, as well as analytical performance and longevity.

Original language	English
Pages (from-to)	494-502
Number of pages	9
Journal	Talanta
Volume	132
DOIs	https://doi.org/10.1016/j.talanta.2014.09.040
Publication status	Published - 15 Jan 2015

Keywords

DIOS
Drug detection
NALDI
NIMS
SALDI

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10.1016/j.talanta.2014.09.040

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title = "Comparison of the performance of different silicon-based SALDI substrates for illicit drug detection",

abstract = "Surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) is an emerging technique used for the detection of small molecules (<700 Da) such as illicit drugs. In recent times, this technique has been employed for the detection of illicit drugs in various body fluids including saliva. Three common SALDI techniques, desorption ionization on porous silicon (DIOS), nanostructure-initiator mass spectrometry (NIMS) and nanostructured laser desorption ionization (NALDI{\texttrademark}) are compared for the detection of four drug classes, amphetamines, benzodiazepines, opiates and tropane alkaloids. We focus in our comparison on structural and chemical characteristics, as well as analytical performance and longevity.",

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AU - Guinan, Taryn

AU - Ronci, Maurizio

AU - Vasani, Roshan

AU - Kobus, Hilton

AU - Voelcker, Nicholas

PY - 2015/1/15

Y1 - 2015/1/15

N2 - Surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) is an emerging technique used for the detection of small molecules (<700 Da) such as illicit drugs. In recent times, this technique has been employed for the detection of illicit drugs in various body fluids including saliva. Three common SALDI techniques, desorption ionization on porous silicon (DIOS), nanostructure-initiator mass spectrometry (NIMS) and nanostructured laser desorption ionization (NALDI™) are compared for the detection of four drug classes, amphetamines, benzodiazepines, opiates and tropane alkaloids. We focus in our comparison on structural and chemical characteristics, as well as analytical performance and longevity.

AB - Surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) is an emerging technique used for the detection of small molecules (<700 Da) such as illicit drugs. In recent times, this technique has been employed for the detection of illicit drugs in various body fluids including saliva. Three common SALDI techniques, desorption ionization on porous silicon (DIOS), nanostructure-initiator mass spectrometry (NIMS) and nanostructured laser desorption ionization (NALDI™) are compared for the detection of four drug classes, amphetamines, benzodiazepines, opiates and tropane alkaloids. We focus in our comparison on structural and chemical characteristics, as well as analytical performance and longevity.

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KW - NIMS

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JO - Talanta

JF - Talanta

ER -

Comparison of the performance of different silicon-based SALDI substrates for illicit drug detection

Abstract

Keywords

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