Comparison of the performance of different silicon-based SALDI substrates for illicit drug detection

Taryn Guinan, Maurizio Ronci, Roshan Vasani, Hilton Kobus, Nicholas Voelcker

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    Surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) is an emerging technique used for the detection of small molecules (<700 Da) such as illicit drugs. In recent times, this technique has been employed for the detection of illicit drugs in various body fluids including saliva. Three common SALDI techniques, desorption ionization on porous silicon (DIOS), nanostructure-initiator mass spectrometry (NIMS) and nanostructured laser desorption ionization (NALDI) are compared for the detection of four drug classes, amphetamines, benzodiazepines, opiates and tropane alkaloids. We focus in our comparison on structural and chemical characteristics, as well as analytical performance and longevity.

    Original languageEnglish
    Pages (from-to)494-502
    Number of pages9
    JournalTalanta
    Volume132
    DOIs
    Publication statusPublished - 15 Jan 2015

    Keywords

    • DIOS
    • Drug detection
    • NALDI
    • NIMS
    • SALDI

    Fingerprint Dive into the research topics of 'Comparison of the performance of different silicon-based SALDI substrates for illicit drug detection'. Together they form a unique fingerprint.

    Cite this