Compassionate access anti-tumour necrosis factor-α therapy for ulcerative colitis in Australia: The benefits to patients

The Australian Inflammatory Bowel Disease Association (AIBDA), P. Bampton

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The efficacy of infliximab has been demonstrated in patients with both acute severe and moderate-severe ulcerative colitis (UC). However, there is a need for 'real-life data' to ensure that conclusions from trial settings are applicable in usual care. We therefore examined the national experience of anti-tumour necrosis factor-α (TNF-α) therapy in UC. Methods: Case notes review of patients with UC who had received compassionate access (CA) anti-TNF-α therapy from prospectively maintained inflammatory bowel disease databases of six Australian adult teaching hospitals. Results: Patients either received drug for acute severe UC (ASUC) failing steroids (n = 29) or for medically refractory UC (MRUC) (n = 35). In ASUC, the treating physicians judged that anti-TNF-α therapy was successful in 20/29 patients (69%); in these cases, anti-TNF-α was able to be discontinued (after 1-3 infusions in 19/20 responders) as clinical remission was achieved. Consistent with this perceived benefit, only 7/29 (24%) subsequently underwent colectomy during a median follow up of 12 months (interquartile range (IQR) 5-16). Eight of the 35 patients with MRUC (23%) required colectomy during a median follow up of 28 months (IQR 11-43). The majority of these patients (20/35 or 57%) had anti-TNF-α therapy for ≥4 months, whereas, 27/29 (93%) of ASUC patients had CA for ≤3 months. Conclusions: These data show an excellent overall benefit for anti-TNF-α therapy in both ASUC and MRUC. In particular, only short-duration anti-TNF-α was required in ASUC. These real-life data thus support the clinical trial data and should lead to broader use of this therapy in UC.

Original languageEnglish
Pages (from-to)659-666
Number of pages8
JournalInternal Medicine Journal
Volume45
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • Colectomy
  • Inflammatory bowel disease
  • Monoclonal antibody
  • Tumour necrosis factor-α
  • Ulcerative colitis

Fingerprint Dive into the research topics of 'Compassionate access anti-tumour necrosis factor-α therapy for ulcerative colitis in Australia: The benefits to patients'. Together they form a unique fingerprint.

  • Cite this