Compensatory renal hypertrophy following nephrectomy: When and how?

Darling Rojas-Canales, Jordan Li, Leek Makuei, Jonathan Gleadle

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Following surgical removal of one kidney, the other enlarges and increases its function. The mechanism for the sensing of this change and the growth is incompletely understood but begins within days and compensatory renal hypertrophy (CRH) is the dominant contributor to the growth. In many individuals undergoing nephrectomy for cancer or kidney donation this produces a substantial and helpful increase in renal function. Two main mechanisms have been proposed, one in which increased activity by the remaining kidney leads to hypertrophy, the second in which there is release of a kidney specific factor in response to a unilateral nephrectomy that initiates CRH. Whilst multiple growth factors and pathways such as the mTORC pathway have been implicated in experimental studies, their roles and the precise mechanism of CRH are not defined. Unrestrained hypoxia inducible factor activation in renal cancer promotes growth and may play an important role in driving CRH.

Original languageEnglish
Article number13578
Pages (from-to)1225-1232
Number of pages8
JournalNephrology
Volume24
Issue number12
DOIs
Publication statusPublished - 27 Feb 2019

Keywords

  • compensatory renal hypertrophy
  • nephrectomy
  • glomerular filtration rate,
  • living donor
  • renalcell carcinoma

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