Composite fluorescent vesicles based on ionic and cationic amphiphilic calix[4]arenes

Paul Eggers; Thomas Becker; Marissa Melvin; Ramiz Boulos; Eliza James; Natalie Morellini; Alan Harvey; Sarah Dunlop; Melinda Fitzgerald; Keith Stubbs; Colin Raston

doi:10.1039/c2ra20491f

Composite fluorescent vesicles based on ionic and cationic amphiphilic calix[4]arenes

Paul Eggers, Thomas Becker, Marissa Melvin, Ramiz Boulos, Eliza James, Natalie Morellini, Alan Harvey, Sarah Dunlop, Melinda Fitzgerald, Keith Stubbs, Colin Raston

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Amphiphilic calixarenes bearing ionisable phosphonic acid groups or cationic trimethylamine groups attached to the upper rim of calix[4]arenes in the cone conformation, with dodecyl moieties attached to the lower rim, have a high uptake in PC-12 cells, with the calixarenes being localised cytoplasmically. The calixarenes form tightly packed layers, as established using scanning tunnelling microscopy (STM) on atomically flat surfaces, and can form vesicles or micelles. The vesicles have been wrapped in a peptide-glycol coat for enhanced stability.

Original language	English
Pages (from-to)	6250-6257
Number of pages	8
Journal	RSC Advances
Volume	2
Issue number	15
DOIs	https://doi.org/10.1039/c2ra20491f
Publication status	Published - 7 Aug 2012

Access to Document

10.1039/c2ra20491f

Cite this

@article{b1a2e978e7964490b94f97961ad63683,

title = "Composite fluorescent vesicles based on ionic and cationic amphiphilic calix[4]arenes",

abstract = "Amphiphilic calixarenes bearing ionisable phosphonic acid groups or cationic trimethylamine groups attached to the upper rim of calix[4]arenes in the cone conformation, with dodecyl moieties attached to the lower rim, have a high uptake in PC-12 cells, with the calixarenes being localised cytoplasmically. The calixarenes form tightly packed layers, as established using scanning tunnelling microscopy (STM) on atomically flat surfaces, and can form vesicles or micelles. The vesicles have been wrapped in a peptide-glycol coat for enhanced stability.",

author = "Paul Eggers and Thomas Becker and Marissa Melvin and Ramiz Boulos and Eliza James and Natalie Morellini and Alan Harvey and Sarah Dunlop and Melinda Fitzgerald and Keith Stubbs and Colin Raston",

year = "2012",

month = aug,

day = "7",

doi = "10.1039/c2ra20491f",

language = "English",

volume = "2",

pages = "6250--6257",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "15",

}

TY - JOUR

T1 - Composite fluorescent vesicles based on ionic and cationic amphiphilic calix[4]arenes

AU - Eggers, Paul

AU - Becker, Thomas

AU - Melvin, Marissa

AU - Boulos, Ramiz

AU - James, Eliza

AU - Morellini, Natalie

AU - Harvey, Alan

AU - Dunlop, Sarah

AU - Fitzgerald, Melinda

AU - Stubbs, Keith

AU - Raston, Colin

PY - 2012/8/7

Y1 - 2012/8/7

N2 - Amphiphilic calixarenes bearing ionisable phosphonic acid groups or cationic trimethylamine groups attached to the upper rim of calix[4]arenes in the cone conformation, with dodecyl moieties attached to the lower rim, have a high uptake in PC-12 cells, with the calixarenes being localised cytoplasmically. The calixarenes form tightly packed layers, as established using scanning tunnelling microscopy (STM) on atomically flat surfaces, and can form vesicles or micelles. The vesicles have been wrapped in a peptide-glycol coat for enhanced stability.

AB - Amphiphilic calixarenes bearing ionisable phosphonic acid groups or cationic trimethylamine groups attached to the upper rim of calix[4]arenes in the cone conformation, with dodecyl moieties attached to the lower rim, have a high uptake in PC-12 cells, with the calixarenes being localised cytoplasmically. The calixarenes form tightly packed layers, as established using scanning tunnelling microscopy (STM) on atomically flat surfaces, and can form vesicles or micelles. The vesicles have been wrapped in a peptide-glycol coat for enhanced stability.

UR - http://www.scopus.com/inward/record.url?scp=84863889458&partnerID=8YFLogxK

U2 - 10.1039/c2ra20491f

DO - 10.1039/c2ra20491f

M3 - Article

SN - 2046-2069

VL - 2

SP - 6250

EP - 6257

JO - RSC Advances

JF - RSC Advances

IS - 15

ER -

Composite fluorescent vesicles based on ionic and cationic amphiphilic calix[4]arenes

Abstract

Access to Document

Other files and links

Fingerprint

Cite this