Composite fluorescent vesicles based on ionic and cationic amphiphilic calix[4]arenes

Paul Eggers, Thomas Becker, Marissa Melvin, Ramiz Boulos, Eliza James, Natalie Morellini, Alan Harvey, Sarah Dunlop, Melinda Fitzgerald, Keith Stubbs, Colin Raston

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)


    Amphiphilic calixarenes bearing ionisable phosphonic acid groups or cationic trimethylamine groups attached to the upper rim of calix[4]arenes in the cone conformation, with dodecyl moieties attached to the lower rim, have a high uptake in PC-12 cells, with the calixarenes being localised cytoplasmically. The calixarenes form tightly packed layers, as established using scanning tunnelling microscopy (STM) on atomically flat surfaces, and can form vesicles or micelles. The vesicles have been wrapped in a peptide-glycol coat for enhanced stability.

    Original languageEnglish
    Pages (from-to)6250-6257
    Number of pages8
    JournalRSC Advances
    Issue number15
    Publication statusPublished - 7 Aug 2012


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