Concise review: Preclinical studies on human cell-based therapy in rodent ischemic stroke models: Where are we now after a decade?

Wai Khay Leong, Martin Lewis, Simon Koblar

    Research output: Contribution to journalShort survey

    25 Citations (Scopus)

    Abstract

    Stroke, a debilitating brain insult, afflicts millions of individuals globally each year. In the last decade, researchers have investigated cell-based therapy as an alternative strategy to improve neurological outcome following stroke. This concise review critically examines preclinical reports using human adult and fetal stem/progenitor cells in rodent models of ischemic stroke. As we enter the second decade of study, we should aim to optimize our collective likelihood to translational success for stroke victims worldwide. We advocate international consensus recommendations be developed for future preclinical research.

    Original languageEnglish
    Pages (from-to)1040-1043
    Number of pages4
    JournalStem Cells
    Volume31
    Issue number6
    DOIs
    Publication statusPublished - Jun 2013

    Keywords

    • Cell-based therapy
    • Human stem/progenitor cells
    • Ischemic stroke
    • Middle cerebral artery occlusion
    • Rat model

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