Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)

Karishma P. Ramlakhan; Mark R. Johnson; Malgorzata Lelonek; Aly Saad; Zaur Gasimov; Natalia V. Sharashkina; Patrick Thornton; Margaret Arstall; Roger Hall; Jolien W. Roos-Hesselink; ROPAC Investigators Group, ROPAC Executive Committee; ROPAC Investigators; M. Wittwer

doi:10.1016/j.ijcchd.2021.100107

Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)

Karishma P. Ramlakhan
, Mark R. Johnson
, Malgorzata Lelonek
, Aly Saad
, Zaur Gasimov
, Natalia V. Sharashkina
, Patrick Thornton
, Margaret Arstall
, Roger Hall
, Jolien W. Roos-Hesselink
, ROPAC Investigators Group, ROPAC Executive Committee
, ROPAC Investigators
, M. Wittwer

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

2 Downloads (Pure)

Abstract

Pregnancy is a major burden on the maternal cardiovascular system. Hormonal changes cause a drop in systemic vascular resistance and a compensatory volume expansion, leading to a 30–50% increase in cardiac output [1]. Cardiac output peaks at the end of the second trimester and remains on a plateau thereafter, until delivery. During labour, pain, stress and the uterine contractions increase cardiac output by another 25%. These changes, with the abrupt cessation of the increased utero-placental blood flow at delivery with the return of 500–700 mls into the systemic circulation, make the postpartum period high risk for the development of heart failure [2,3]. Additionally, the risk of arrhythmias, thrombosis and aortic dissection is increased during and shortly after pregnancy [3]. The impact of pregnancy on the cardiovascular system may explain why cardiac disease is the leading cause of maternal mortality in high income countries and why women with pre-existing cardiac disease, including congenital heart disease (CHD), are at particular risk.

Original language	English
Article number	100107
Number of pages	7
Journal	International Journal of Cardiology Congenital Heart Disease
Volume	3
DOIs	https://doi.org/10.1016/j.ijcchd.2021.100107
Publication status	Published - May 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Congenital heart disease
Maternal health
Observational registry
Pregnancy

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10.1016/j.ijcchd.2021.100107Licence: CC BY

Published versionFinal published version, 1.42 MBLicence: CC BY

Cite this

Ramlakhan, K. P., Johnson, M. R., Lelonek, M., Saad, A., Gasimov, Z., Sharashkina, N. V., Thornton, P., Arstall, M., Hall, R., Roos-Hesselink, J. W., ROPAC Investigators Group, ROPAC Executive Committee, ROPAC Investigators, & Wittwer, M. (2021). Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC). International Journal of Cardiology Congenital Heart Disease, 3, Article 100107. https://doi.org/10.1016/j.ijcchd.2021.100107

@article{5f9bb2a3c7f146e68a877bc4a740e941,

title = "Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)",

abstract = "Pregnancy is a major burden on the maternal cardiovascular system. Hormonal changes cause a drop in systemic vascular resistance and a compensatory volume expansion, leading to a 30–50\% increase in cardiac output [1]. Cardiac output peaks at the end of the second trimester and remains on a plateau thereafter, until delivery. During labour, pain, stress and the uterine contractions increase cardiac output by another 25\%. These changes, with the abrupt cessation of the increased utero-placental blood flow at delivery with the return of 500–700 mls into the systemic circulation, make the postpartum period high risk for the development of heart failure [2,3]. Additionally, the risk of arrhythmias, thrombosis and aortic dissection is increased during and shortly after pregnancy [3]. The impact of pregnancy on the cardiovascular system may explain why cardiac disease is the leading cause of maternal mortality in high income countries and why women with pre-existing cardiac disease, including congenital heart disease (CHD), are at particular risk.",

keywords = "Congenital heart disease, Maternal health, Observational registry, Pregnancy",

author = "Ramlakhan, \{Karishma P.\} and Johnson, \{Mark R.\} and Malgorzata Lelonek and Aly Saad and Zaur Gasimov and Sharashkina, \{Natalia V.\} and Patrick Thornton and Margaret Arstall and Roger Hall and Roos-Hesselink, \{Jolien W.\} and \{ROPAC Investigators Group, ROPAC Executive Committee\} and Joerg Stein and Parsonage, \{William Anthony\} and Werner Budts and \{De Backer\}, Julie and Jasmin Grewal and Ariane Marelli and Harald Kaemmerer and Guillaume Jondeau and Mark Johnson and Maggioni, \{Aldo P.\} and Luigi Tavazzi and Ulf Thilen and Uri Elkayam and Catherine Otto and Karen Sliwa and \{ROPAC Investigators\} and A. Aquieri and A. Saad and Vega, \{H. Ruda\} and J. Hojman and Caparros, \{J. M.\} and Blanco, \{M. Vazquez\} and M. Arstall and Chung, \{C. M.\} and G. Mahadavan and E. Aldridge and M. Wittwer and Chow, \{Y. Y.\} and Parsonage, \{W. A.\} and K. Lust and N. Collins and G. Warner and R. Hatton and A. Gordon and E. Nyman and J. Stein and E. Donhauser and H. Gabriel and A. Bahshaliyev and F. Guliyev and I. Hasanova and T. Jahangirov and Z. Gasimov and A. Salim and Ahmed, \{C. M.\} and F. Begum and Hoque, \{M. H.\} and M. Mahmood and Islam, \{M. N.\} and Haque, \{P. P.\} and Banerjee, \{S. K.\} and T. Parveen and M. Morissens and \{De Backer\}, J. and L. Demulier and \{de Hosson\}, M. and W. Budts and M. Beckx and M. Kozic and M. Lovric and T. Kovacevic-Preradovic and N. Chilingirova and P. Kratunkov and N. Wahab and S. McLean and E. Gordon and L. Walter and A. Marelli and Montesclaros, \{A. R.\} and G. Monsalve and C. Rodriguez and F. Balthazar and V. Quintero and W. Palacio and Cadavid, \{L. A.Mej{\'i}a\} and Ortiz, \{E. Munoz\} and Hoyos, \{F. Fortich\} and Guerrero, \{E. Arevalo\} and Ricardo, \{J. Gandara\} and Penagos, \{J. Velasquez\} and Z. Vavera and J. Popelova and N. Vejlstrup and L. Gr{\o}nbeck and M. Johansen and A. Ersboll and Y. Elrakshy and K. Eltamawy and \{Abd-El Aziz\}, \{M. Gamal\} and \{El Nagar\}, A. and H. Ebaid and Elenin, \{H. Abo\} and M. Saed and S. Farag and W. Makled and K. Sorour and Z. Ashour and G. El-Sayed and \{Meguid Mahdy\}, \{M. Abdel\} and N. Taha and A. Dardeer and M. Shabaan and M. Ali and P. Moceri and G. Duthoit and M. Gouton and J. Nizard and L. Baris and S. Cohen and M. Ladouceur and D. Khimoud and B. Iung and F. Berger and A. Olsson and U. Gembruch and Merz, \{W. M.\} and E. Reinert and S. Clade and Y. Kliesch and C. Wald and C. Sinning and R. Kozlik-Feldmann and S. Blankenberg and E. Zengin-Sahm and G. Mueller and M. Hillebrand and P. Hauck and \{von Kodolitsch\}, Y. and N. Zarniko and Baumgartner, \{Muenster H.\} and R. Schmidt and A. Hellige and O. Tutarel and H. Kaemmerer and B. Kuschel and N. Nagdyman and R. Motz and D. Maisuradze and A. Frogoudaki and E. Iliodromitis and M. Anastasiou-Nana and D. Triantafyllis and G. Bekiaris and H. Karvounis and G. Giannakoulas and D. Ntiloudi and Mouratoglou, \{S. A.\} and A. Temesvari and H. Balint and D. Kohalmi and B. Merkely and C. Liptai and A. Nemes and T. Forster and A. Kalapos and K. Berek and K. Havasi and N. Ambrus and A. Shelke and R. Kawade and S. Patil and E. Martanto and Aprami, \{T. M.\} and A. Purnomowati and Cool, \{C. J.\} and M. Hasan and R. Akbar and S. Hidayat and Dewi, \{T. I.\} and W. Permadi and Soedarsono, \{D. A.\} and Ansari-Ramandi, \{M. M.\} and N. Samiei and A. Tabib and F. Kashfi and S. Ansari-Ramandi and S. Rezaei and Farhan, \{H. Ali\} and A. Al-Hussein and G. Al-Saedi and G. Mahmood and Yaseen, \{I. F.\} and L. Al-Yousuf and M. AlBayati and S. Mahmood and S. Raheem and T. AlHaidari and Z. Dakhil and P. Thornton and J. Donnelly and M. Bowen and A. Blatt and G. Elbaz-Greener and A. Shotan and S. Yalonetsky and S. Goland and M. Biener and Assenza, \{G. Egidy\} and M. Bonvicini and A. Donti and A. Bulgarelli and D. Prandstraller and C. Romeo and R. Crepaz and E. Sciatti and M. Metra and R. Orabona and Ali, \{L. Ait\} and P. Festa and V. Fesslova and C. Bonanomi and M. Calcagnino and F. Lombardi and Colli, \{A. M.\} and Ossola, \{M. W.\} and C. Gobbi and E. Gherbesi and L. Tondi and M. Schiavone and M. Squillace and Carmina, \{M. G.\} and A. Maina and C. Macchi and E. Gollo and Comoglio, \{F. M.\} and N. Montali and P. Re and R. Bordese and T. Todros and V. Donvito and Marra, \{W. Grosso\} and G. Sinagra and \{D'Agata Mottolese\}, B. and M. Bobbo and V. Gesuete and S. Rakar and F. Ramani and K. Niwa",

year = "2021",

month = may,

doi = "10.1016/j.ijcchd.2021.100107",

language = "English",

volume = "3",

journal = "International Journal of Cardiology Congenital Heart Disease",

issn = "2666-6685",

publisher = "Elsevier B.V.",

}

Ramlakhan, KP, Johnson, MR, Lelonek, M, Saad, A, Gasimov, Z, Sharashkina, NV, Thornton, P, Arstall, M, Hall, R, Roos-Hesselink, JW, ROPAC Investigators Group, ROPAC Executive Committee, ROPAC Investigators & Wittwer, M 2021, 'Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)', International Journal of Cardiology Congenital Heart Disease, vol. 3, 100107. https://doi.org/10.1016/j.ijcchd.2021.100107

TY - JOUR

T1 - Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)

AU - Ramlakhan, Karishma P.

AU - Johnson, Mark R.

AU - Lelonek, Malgorzata

AU - Saad, Aly

AU - Gasimov, Zaur

AU - Sharashkina, Natalia V.

AU - Thornton, Patrick

AU - Arstall, Margaret

AU - Hall, Roger

AU - Roos-Hesselink, Jolien W.

AU - ROPAC Investigators Group, ROPAC Executive Committee

AU - Stein, Joerg

AU - Parsonage, William Anthony

AU - Budts, Werner

AU - De Backer, Julie

AU - Grewal, Jasmin

AU - Marelli, Ariane

AU - Kaemmerer, Harald

AU - Jondeau, Guillaume

AU - Johnson, Mark

AU - Maggioni, Aldo P.

AU - Tavazzi, Luigi

AU - Thilen, Ulf

AU - Elkayam, Uri

AU - Otto, Catherine

AU - Sliwa, Karen

AU - ROPAC Investigators

AU - Aquieri, A.

AU - Saad, A.

AU - Vega, H. Ruda

AU - Hojman, J.

AU - Caparros, J. M.

AU - Blanco, M. Vazquez

AU - Arstall, M.

AU - Chung, C. M.

AU - Mahadavan, G.

AU - Aldridge, E.

AU - Wittwer, M.

AU - Chow, Y. Y.

AU - Parsonage, W. A.

AU - Lust, K.

AU - Collins, N.

AU - Warner, G.

AU - Hatton, R.

AU - Gordon, A.

AU - Nyman, E.

AU - Stein, J.

AU - Donhauser, E.

AU - Gabriel, H.

AU - Bahshaliyev, A.

AU - Guliyev, F.

AU - Hasanova, I.

AU - Jahangirov, T.

AU - Gasimov, Z.

AU - Salim, A.

AU - Ahmed, C. M.

AU - Begum, F.

AU - Hoque, M. H.

AU - Mahmood, M.

AU - Islam, M. N.

AU - Haque, P. P.

AU - Banerjee, S. K.

AU - Parveen, T.

AU - Morissens, M.

AU - De Backer, J.

AU - Demulier, L.

AU - de Hosson, M.

AU - Budts, W.

AU - Beckx, M.

AU - Kozic, M.

AU - Lovric, M.

AU - Kovacevic-Preradovic, T.

AU - Chilingirova, N.

AU - Kratunkov, P.

AU - Wahab, N.

AU - McLean, S.

AU - Gordon, E.

AU - Walter, L.

AU - Marelli, A.

AU - Montesclaros, A. R.

AU - Monsalve, G.

AU - Rodriguez, C.

AU - Balthazar, F.

AU - Quintero, V.

AU - Palacio, W.

AU - Cadavid, L. A.Mejía

AU - Ortiz, E. Munoz

AU - Hoyos, F. Fortich

AU - Guerrero, E. Arevalo

AU - Ricardo, J. Gandara

AU - Penagos, J. Velasquez

AU - Vavera, Z.

AU - Popelova, J.

AU - Vejlstrup, N.

AU - Grønbeck, L.

AU - Johansen, M.

AU - Ersboll, A.

AU - Elrakshy, Y.

AU - Eltamawy, K.

AU - Abd-El Aziz, M. Gamal

AU - El Nagar, A.

AU - Ebaid, H.

AU - Elenin, H. Abo

AU - Saed, M.

AU - Farag, S.

AU - Makled, W.

AU - Sorour, K.

AU - Ashour, Z.

AU - El-Sayed, G.

AU - Meguid Mahdy, M. Abdel

AU - Taha, N.

AU - Dardeer, A.

AU - Shabaan, M.

AU - Ali, M.

AU - Moceri, P.

AU - Duthoit, G.

AU - Gouton, M.

AU - Nizard, J.

AU - Baris, L.

AU - Cohen, S.

AU - Ladouceur, M.

AU - Khimoud, D.

AU - Iung, B.

AU - Berger, F.

AU - Olsson, A.

AU - Gembruch, U.

AU - Merz, W. M.

AU - Reinert, E.

AU - Clade, S.

AU - Kliesch, Y.

AU - Wald, C.

AU - Sinning, C.

AU - Kozlik-Feldmann, R.

AU - Blankenberg, S.

AU - Zengin-Sahm, E.

AU - Mueller, G.

AU - Hillebrand, M.

AU - Hauck, P.

AU - von Kodolitsch, Y.

AU - Zarniko, N.

AU - Baumgartner, Muenster H.

AU - Schmidt, R.

AU - Hellige, A.

AU - Tutarel, O.

AU - Kaemmerer, H.

AU - Kuschel, B.

AU - Nagdyman, N.

AU - Motz, R.

AU - Maisuradze, D.

AU - Frogoudaki, A.

AU - Iliodromitis, E.

AU - Anastasiou-Nana, M.

AU - Triantafyllis, D.

AU - Bekiaris, G.

AU - Karvounis, H.

AU - Giannakoulas, G.

AU - Ntiloudi, D.

AU - Mouratoglou, S. A.

AU - Temesvari, A.

AU - Balint, H.

AU - Kohalmi, D.

AU - Merkely, B.

AU - Liptai, C.

AU - Nemes, A.

AU - Forster, T.

AU - Kalapos, A.

AU - Berek, K.

AU - Havasi, K.

AU - Ambrus, N.

AU - Shelke, A.

AU - Kawade, R.

AU - Patil, S.

AU - Martanto, E.

AU - Aprami, T. M.

AU - Purnomowati, A.

AU - Cool, C. J.

AU - Hasan, M.

AU - Akbar, R.

AU - Hidayat, S.

AU - Dewi, T. I.

AU - Permadi, W.

AU - Soedarsono, D. A.

AU - Ansari-Ramandi, M. M.

AU - Samiei, N.

AU - Tabib, A.

AU - Kashfi, F.

AU - Ansari-Ramandi, S.

AU - Rezaei, S.

AU - Farhan, H. Ali

AU - Al-Hussein, A.

AU - Al-Saedi, G.

AU - Mahmood, G.

AU - Yaseen, I. F.

AU - Al-Yousuf, L.

AU - AlBayati, M.

AU - Mahmood, S.

AU - Raheem, S.

AU - AlHaidari, T.

AU - Dakhil, Z.

AU - Thornton, P.

AU - Donnelly, J.

AU - Bowen, M.

AU - Blatt, A.

AU - Elbaz-Greener, G.

AU - Shotan, A.

AU - Yalonetsky, S.

AU - Goland, S.

AU - Biener, M.

AU - Assenza, G. Egidy

AU - Bonvicini, M.

AU - Donti, A.

AU - Bulgarelli, A.

AU - Prandstraller, D.

AU - Romeo, C.

AU - Crepaz, R.

AU - Sciatti, E.

AU - Metra, M.

AU - Orabona, R.

AU - Ali, L. Ait

AU - Festa, P.

AU - Fesslova, V.

AU - Bonanomi, C.

AU - Calcagnino, M.

AU - Lombardi, F.

AU - Colli, A. M.

AU - Ossola, M. W.

AU - Gobbi, C.

AU - Gherbesi, E.

AU - Tondi, L.

AU - Schiavone, M.

AU - Squillace, M.

AU - Carmina, M. G.

AU - Maina, A.

AU - Macchi, C.

AU - Gollo, E.

AU - Comoglio, F. M.

AU - Montali, N.

AU - Re, P.

AU - Bordese, R.

AU - Todros, T.

AU - Donvito, V.

AU - Marra, W. Grosso

AU - Sinagra, G.

AU - D'Agata Mottolese, B.

AU - Bobbo, M.

AU - Gesuete, V.

AU - Rakar, S.

AU - Ramani, F.

AU - Niwa, K.

PY - 2021/5

Y1 - 2021/5

N2 - Pregnancy is a major burden on the maternal cardiovascular system. Hormonal changes cause a drop in systemic vascular resistance and a compensatory volume expansion, leading to a 30–50% increase in cardiac output [1]. Cardiac output peaks at the end of the second trimester and remains on a plateau thereafter, until delivery. During labour, pain, stress and the uterine contractions increase cardiac output by another 25%. These changes, with the abrupt cessation of the increased utero-placental blood flow at delivery with the return of 500–700 mls into the systemic circulation, make the postpartum period high risk for the development of heart failure [2,3]. Additionally, the risk of arrhythmias, thrombosis and aortic dissection is increased during and shortly after pregnancy [3]. The impact of pregnancy on the cardiovascular system may explain why cardiac disease is the leading cause of maternal mortality in high income countries and why women with pre-existing cardiac disease, including congenital heart disease (CHD), are at particular risk.

AB - Pregnancy is a major burden on the maternal cardiovascular system. Hormonal changes cause a drop in systemic vascular resistance and a compensatory volume expansion, leading to a 30–50% increase in cardiac output [1]. Cardiac output peaks at the end of the second trimester and remains on a plateau thereafter, until delivery. During labour, pain, stress and the uterine contractions increase cardiac output by another 25%. These changes, with the abrupt cessation of the increased utero-placental blood flow at delivery with the return of 500–700 mls into the systemic circulation, make the postpartum period high risk for the development of heart failure [2,3]. Additionally, the risk of arrhythmias, thrombosis and aortic dissection is increased during and shortly after pregnancy [3]. The impact of pregnancy on the cardiovascular system may explain why cardiac disease is the leading cause of maternal mortality in high income countries and why women with pre-existing cardiac disease, including congenital heart disease (CHD), are at particular risk.

KW - Congenital heart disease

KW - Maternal health

KW - Observational registry

KW - Pregnancy

UR - https://www.scopus.com/pages/publications/85119365924

U2 - 10.1016/j.ijcchd.2021.100107

DO - 10.1016/j.ijcchd.2021.100107

M3 - Article

AN - SCOPUS:85119365924

SN - 2666-6685

VL - 3

JO - International Journal of Cardiology Congenital Heart Disease

JF - International Journal of Cardiology Congenital Heart Disease

M1 - 100107

ER -

Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)

Abstract

UN SDGs

Keywords

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