Connecting the dots: the role of genetics in posterior vitreous detachment

Rajya L. Gurung; Stewart Lake; Shane Durkin; David Sia; Jagjit Gilhotra; Weng Onn Chan

doi:10.1007/s00417-025-06869-8

Connecting the dots: the role of genetics in posterior vitreous detachment

Rajya L. Gurung, Stewart Lake, Shane Durkin, David Sia, Jagjit Gilhotra, Weng Onn Chan

Research output: Contribution to journal › Short survey › peer-review

Abstract

The vitreous is a transparent homogenous gel comprised predominantly of water. It is firmly attached to the internal limiting membrane in young healthy individuals. As part of the physiological aging process, the separation of the posterior vitreous cortex from the internal limiting membrane is called physiological posterior vitreous detachment (PVD), which usually occurs without ocular complications. On the contrary, anomalous PVD can have various sight-threatening complications. The cause of this difference is poorly understood and is a topic of future research. Further, newer evidence indicates that anomalous PVD may be genetically influenced.

Original language	English
Number of pages	9
Journal	Graefe's Archive For Clinical and Experimental Ophthalmology
DOIs	https://doi.org/10.1007/s00417-025-06869-8
Publication status	E-pub ahead of print - 18 Jun 2025
Externally published	Yes

Keywords

Anomalous posterior vitreous detachment
Genetics
Pathogenesis
Vitreous

Access to Document

10.1007/s00417-025-06869-8Licence: In Copyright

https://rdcu.be/eucVZLicence: In Copyright

Cite this

@article{9e946c9f853e4d24bf65748bed6d35f1,

title = "Connecting the dots: the role of genetics in posterior vitreous detachment",

abstract = "The vitreous is a transparent homogenous gel comprised predominantly of water. It is firmly attached to the internal limiting membrane in young healthy individuals. As part of the physiological aging process, the separation of the posterior vitreous cortex from the internal limiting membrane is called physiological posterior vitreous detachment (PVD), which usually occurs without ocular complications. On the contrary, anomalous PVD can have various sight-threatening complications. The cause of this difference is poorly understood and is a topic of future research. Further, newer evidence indicates that anomalous PVD may be genetically influenced.",

keywords = "Anomalous posterior vitreous detachment, Genetics, Pathogenesis, Vitreous",

author = "Gurung, {Rajya L.} and Stewart Lake and Shane Durkin and David Sia and Jagjit Gilhotra and Chan, {Weng Onn}",

year = "2025",

month = jun,

day = "18",

doi = "10.1007/s00417-025-06869-8",

language = "English",

journal = "Graefe's Archive For Clinical and Experimental Ophthalmology",

issn = "0721-832X",

publisher = "Springer Verlag",

}

TY - JOUR

T1 - Connecting the dots

T2 - the role of genetics in posterior vitreous detachment

AU - Gurung, Rajya L.

AU - Lake, Stewart

AU - Durkin, Shane

AU - Sia, David

AU - Gilhotra, Jagjit

AU - Chan, Weng Onn

PY - 2025/6/18

Y1 - 2025/6/18

N2 - The vitreous is a transparent homogenous gel comprised predominantly of water. It is firmly attached to the internal limiting membrane in young healthy individuals. As part of the physiological aging process, the separation of the posterior vitreous cortex from the internal limiting membrane is called physiological posterior vitreous detachment (PVD), which usually occurs without ocular complications. On the contrary, anomalous PVD can have various sight-threatening complications. The cause of this difference is poorly understood and is a topic of future research. Further, newer evidence indicates that anomalous PVD may be genetically influenced.

AB - The vitreous is a transparent homogenous gel comprised predominantly of water. It is firmly attached to the internal limiting membrane in young healthy individuals. As part of the physiological aging process, the separation of the posterior vitreous cortex from the internal limiting membrane is called physiological posterior vitreous detachment (PVD), which usually occurs without ocular complications. On the contrary, anomalous PVD can have various sight-threatening complications. The cause of this difference is poorly understood and is a topic of future research. Further, newer evidence indicates that anomalous PVD may be genetically influenced.

KW - Anomalous posterior vitreous detachment

KW - Genetics

KW - Pathogenesis

KW - Vitreous

UR - http://www.scopus.com/inward/record.url?scp=105008321412&partnerID=8YFLogxK

U2 - 10.1007/s00417-025-06869-8

DO - 10.1007/s00417-025-06869-8

M3 - Short survey

AN - SCOPUS:105008321412

SN - 0721-832X

JO - Graefe's Archive For Clinical and Experimental Ophthalmology

JF - Graefe's Archive For Clinical and Experimental Ophthalmology

ER -

Connecting the dots: the role of genetics in posterior vitreous detachment

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this