Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 2

Jessica Shipley; James Beharry; Wei Yeh; Nabil Seery; Yi Chao Foong; Darshini Ayton; Pakeeran Siriratnam; Tracie Tan; Heidi Beadnall; Joshua Barton; Francesca Bridge; Robb Wesselingh; Lisa Taylor; Louise Rath; Jodi Haartsen; Mohammad Gadi; Cassie Nesbitt; Michael Zhong; Victoria Cushing; Fiona McKay; Julia Morahan; Benjamin Peter Trewin; Izanne Roos; Mark Marriott; Ai Lan Nguyen; Emma Downey; Joanne Crosby; Julian Bosco; Jennifer Taylor; Lauren Giles; Nevin John; Ernest Butler; Anneke van der Walt; Helmut Butzkueven; Stefan Blum; Marion Simpson; Mark Slee; Sudarshini Ramanathan; Todd Hardy; Richard A.L. Macdonell; Katherine Buzzard; Deborah F. Mason; Jeannette Lechner-Scott; Trevor J. Kilpatrick; Tomas Kalincik; Bruce V. Taylor; Simon A. Broadley; Stephen Reddel; Douglas Johnson; Mastura Monif; the MS Interest Group, Australian and New Zealand Association of Neurologists

doi:10.5694/mja2.52577

Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 2

Jessica Shipley, James Beharry, Wei Yeh, Nabil Seery, Yi Chao Foong, Darshini Ayton, Pakeeran Siriratnam, Tracie Tan, Heidi Beadnall, Joshua Barton, Francesca Bridge, Robb Wesselingh, Lisa Taylor, Louise Rath, Jodi Haartsen, Mohammad Gadi, Cassie Nesbitt, Michael Zhong, Victoria Cushing, Fiona McKayJulia Morahan, Benjamin Peter Trewin, Izanne Roos, Mark Marriott, Ai Lan Nguyen, Emma Downey, Joanne Crosby, Julian Bosco, Jennifer Taylor, Lauren Giles, Nevin John, Ernest Butler, Anneke van der Walt, Helmut Butzkueven, Stefan Blum, Marion Simpson, Mark Slee, Sudarshini Ramanathan, Todd Hardy, Richard A.L. Macdonell, Katherine Buzzard, Deborah F. Mason, Jeannette Lechner-Scott, Trevor J. Kilpatrick, Tomas Kalincik, Bruce V. Taylor, Simon A. Broadley, Stephen Reddel, Douglas Johnson, Mastura Monif, the MS Interest Group, Australian and New Zealand Association of Neurologists

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

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Abstract

Introduction: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with rapidly evolving treatment options and strategies. An iterative modified Delphi process was used to develop 80 consensus recommendations for the management of MS in Australia and New Zealand. Part 1 of these guidelines includes recommendations related to selection of initial disease-modifying therapy (DMT) for MS, assessments before commencing DMT, monitoring disease activity on DMT, switching DMT, and discontinuing DMT.

Main recommendations: This article, Part 2, covers recommendations related to risk mitigation during treatment with DMT, managing DMT in special situations (including pregnancy, postpartum, breastfeeding, active infection including COVID-19, and malignancy), general lifestyle measures for MS, acute MS relapses, and symptomatic treatments.

Changes in management as a result of the guidelines: Together with Part 1, this consensus statement provides practical guidance for clinicians involved in the care of adults (≥ 18 years old) with MS in Australia and New Zealand. A safe, effective and comprehensive approach to managing MS is crucial for improving long term outcomes and quality of life in individuals affected by MS.

Original language	English
Pages (from-to)	365-371
Number of pages	7
Journal	Medical Journal of Australia
Volume	222
Issue number	7
Early online date	9 Feb 2025
DOIs	https://doi.org/10.5694/mja2.52577
Publication status	Published - 21 Apr 2025

Keywords

Multiple sclerosis
Patient care
Patient management

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Shipley, J., Beharry, J., Yeh, W., Seery, N., Foong, Y. C., Ayton, D., Siriratnam, P., Tan, T., Beadnall, H., Barton, J., Bridge, F., Wesselingh, R., Taylor, L., Rath, L., Haartsen, J., Gadi, M., Nesbitt, C., Zhong, M., Cushing, V., ... the MS Interest Group, Australian and New Zealand Association of Neurologists (2025). Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 2. Medical Journal of Australia, 222(7), 365-371. https://doi.org/10.5694/mja2.52577

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title = "Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 2",

abstract = "Introduction: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with rapidly evolving treatment options and strategies. An iterative modified Delphi process was used to develop 80 consensus recommendations for the management of MS in Australia and New Zealand. Part 1 of these guidelines includes recommendations related to selection of initial disease-modifying therapy (DMT) for MS, assessments before commencing DMT, monitoring disease activity on DMT, switching DMT, and discontinuing DMT. Main recommendations: This article, Part 2, covers recommendations related to risk mitigation during treatment with DMT, managing DMT in special situations (including pregnancy, postpartum, breastfeeding, active infection including COVID-19, and malignancy), general lifestyle measures for MS, acute MS relapses, and symptomatic treatments. Changes in management as a result of the guidelines: Together with Part 1, this consensus statement provides practical guidance for clinicians involved in the care of adults (≥ 18 years old) with MS in Australia and New Zealand. A safe, effective and comprehensive approach to managing MS is crucial for improving long term outcomes and quality of life in individuals affected by MS.",

keywords = "Multiple sclerosis, Patient care, Patient management",

author = "Jessica Shipley and James Beharry and Wei Yeh and Nabil Seery and Foong, {Yi Chao} and Darshini Ayton and Pakeeran Siriratnam and Tracie Tan and Heidi Beadnall and Joshua Barton and Francesca Bridge and Robb Wesselingh and Lisa Taylor and Louise Rath and Jodi Haartsen and Mohammad Gadi and Cassie Nesbitt and Michael Zhong and Victoria Cushing and Fiona McKay and Julia Morahan and Trewin, {Benjamin Peter} and Izanne Roos and Mark Marriott and Nguyen, {Ai Lan} and Emma Downey and Joanne Crosby and Julian Bosco and Jennifer Taylor and Lauren Giles and Nevin John and Ernest Butler and {van der Walt}, Anneke and Helmut Butzkueven and Stefan Blum and Marion Simpson and Mark Slee and Sudarshini Ramanathan and Todd Hardy and Macdonell, {Richard A.L.} and Katherine Buzzard and Mason, {Deborah F.} and Jeannette Lechner-Scott and Kilpatrick, {Trevor J.} and Tomas Kalincik and Taylor, {Bruce V.} and Broadley, {Simon A.} and Stephen Reddel and Douglas Johnson and Mastura Monif and {the MS Interest Group, Australian and New Zealand Association of Neurologists}",

year = "2025",

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day = "21",

doi = "10.5694/mja2.52577",

language = "English",

volume = "222",

pages = "365--371",

journal = "Medical Journal of Australia",

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Shipley, J, Beharry, J, Yeh, W, Seery, N, Foong, YC, Ayton, D, Siriratnam, P, Tan, T, Beadnall, H, Barton, J, Bridge, F, Wesselingh, R, Taylor, L, Rath, L, Haartsen, J, Gadi, M, Nesbitt, C, Zhong, M, Cushing, V, McKay, F, Morahan, J, Trewin, BP, Roos, I, Marriott, M, Nguyen, AL, Downey, E, Crosby, J, Bosco, J, Taylor, J, Giles, L, John, N, Butler, E, van der Walt, A, Butzkueven, H, Blum, S, Simpson, M, Slee, M, Ramanathan, S, Hardy, T, Macdonell, RAL, Buzzard, K, Mason, DF, Lechner-Scott, J, Kilpatrick, TJ, Kalincik, T, Taylor, BV, Broadley, SA, Reddel, S, Johnson, D, Monif, M & the MS Interest Group, Australian and New Zealand Association of Neurologists 2025, 'Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 2', Medical Journal of Australia, vol. 222, no. 7, pp. 365-371. https://doi.org/10.5694/mja2.52577

TY - JOUR

T1 - Consensus recommendations on multiple sclerosis management in Australia and New Zealand

T2 - part 2

AU - Shipley, Jessica

AU - Beharry, James

AU - Yeh, Wei

AU - Seery, Nabil

AU - Foong, Yi Chao

AU - Ayton, Darshini

AU - Siriratnam, Pakeeran

AU - Tan, Tracie

AU - Beadnall, Heidi

AU - Barton, Joshua

AU - Bridge, Francesca

AU - Wesselingh, Robb

AU - Taylor, Lisa

AU - Rath, Louise

AU - Haartsen, Jodi

AU - Gadi, Mohammad

AU - Nesbitt, Cassie

AU - Zhong, Michael

AU - Cushing, Victoria

AU - McKay, Fiona

AU - Morahan, Julia

AU - Trewin, Benjamin Peter

AU - Roos, Izanne

AU - Marriott, Mark

AU - Nguyen, Ai Lan

AU - Downey, Emma

AU - Crosby, Joanne

AU - Bosco, Julian

AU - Taylor, Jennifer

AU - Giles, Lauren

AU - John, Nevin

AU - Butler, Ernest

AU - van der Walt, Anneke

AU - Butzkueven, Helmut

AU - Blum, Stefan

AU - Simpson, Marion

AU - Slee, Mark

AU - Ramanathan, Sudarshini

AU - Hardy, Todd

AU - Macdonell, Richard A.L.

AU - Buzzard, Katherine

AU - Mason, Deborah F.

AU - Lechner-Scott, Jeannette

AU - Kilpatrick, Trevor J.

AU - Kalincik, Tomas

AU - Taylor, Bruce V.

AU - Broadley, Simon A.

AU - Reddel, Stephen

AU - Johnson, Douglas

AU - Monif, Mastura

AU - the MS Interest Group, Australian and New Zealand Association of Neurologists

PY - 2025/4/21

Y1 - 2025/4/21

N2 - Introduction: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with rapidly evolving treatment options and strategies. An iterative modified Delphi process was used to develop 80 consensus recommendations for the management of MS in Australia and New Zealand. Part 1 of these guidelines includes recommendations related to selection of initial disease-modifying therapy (DMT) for MS, assessments before commencing DMT, monitoring disease activity on DMT, switching DMT, and discontinuing DMT. Main recommendations: This article, Part 2, covers recommendations related to risk mitigation during treatment with DMT, managing DMT in special situations (including pregnancy, postpartum, breastfeeding, active infection including COVID-19, and malignancy), general lifestyle measures for MS, acute MS relapses, and symptomatic treatments. Changes in management as a result of the guidelines: Together with Part 1, this consensus statement provides practical guidance for clinicians involved in the care of adults (≥ 18 years old) with MS in Australia and New Zealand. A safe, effective and comprehensive approach to managing MS is crucial for improving long term outcomes and quality of life in individuals affected by MS.

AB - Introduction: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with rapidly evolving treatment options and strategies. An iterative modified Delphi process was used to develop 80 consensus recommendations for the management of MS in Australia and New Zealand. Part 1 of these guidelines includes recommendations related to selection of initial disease-modifying therapy (DMT) for MS, assessments before commencing DMT, monitoring disease activity on DMT, switching DMT, and discontinuing DMT. Main recommendations: This article, Part 2, covers recommendations related to risk mitigation during treatment with DMT, managing DMT in special situations (including pregnancy, postpartum, breastfeeding, active infection including COVID-19, and malignancy), general lifestyle measures for MS, acute MS relapses, and symptomatic treatments. Changes in management as a result of the guidelines: Together with Part 1, this consensus statement provides practical guidance for clinicians involved in the care of adults (≥ 18 years old) with MS in Australia and New Zealand. A safe, effective and comprehensive approach to managing MS is crucial for improving long term outcomes and quality of life in individuals affected by MS.

KW - Multiple sclerosis

KW - Patient care

KW - Patient management

UR - http://www.scopus.com/inward/record.url?scp=85217556874&partnerID=8YFLogxK

U2 - 10.5694/mja2.52577

DO - 10.5694/mja2.52577

M3 - Article

AN - SCOPUS:85217556874

SN - 0025-729X

VL - 222

SP - 365

EP - 371

JO - Medical Journal of Australia

JF - Medical Journal of Australia

IS - 7

ER -

Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 2

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