Considering relatives when assessing the evidential strength of mixed DNA profiles

Duncan Taylor; Jo-Anne Bright; John Buckleton

doi:10.1016/j.fsigen.2014.08.015

Considering relatives when assessing the evidential strength of mixed DNA profiles

Duncan Taylor, Jo-Anne Bright, John Buckleton

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Sophisticated methods of DNA profile interpretation have enabled scientists to calculate weights for genotype sets proposed to explain some observed data. Using standard formulae these weights can be incorporated into an LR calculation that considers two competing propositions. We demonstrate here how consideration of relatedness to the person of interest can be incorporated into a LR calculation and how the same calculation can be used for familial searches of complex mixtures. We provide a general formula that can be used in semi or fully automated methods of calculation and demonstrate their use by working through an example.

Original language	English
Pages (from-to)	259-263
Number of pages	5
Journal	Forensic Science International: Genetics
Volume	13
DOIs	https://doi.org/10.1016/j.fsigen.2014.08.015
Publication status	Published - Nov 2014

Keywords

Continuous model
DNA profile interpretation
Likelihood ratio
Mixtures
Relatives
STRmix

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10.1016/j.fsigen.2014.08.015

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abstract = "Sophisticated methods of DNA profile interpretation have enabled scientists to calculate weights for genotype sets proposed to explain some observed data. Using standard formulae these weights can be incorporated into an LR calculation that considers two competing propositions. We demonstrate here how consideration of relatedness to the person of interest can be incorporated into a LR calculation and how the same calculation can be used for familial searches of complex mixtures. We provide a general formula that can be used in semi or fully automated methods of calculation and demonstrate their use by working through an example.",

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AU - Bright, Jo-Anne

AU - Buckleton, John

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AB - Sophisticated methods of DNA profile interpretation have enabled scientists to calculate weights for genotype sets proposed to explain some observed data. Using standard formulae these weights can be incorporated into an LR calculation that considers two competing propositions. We demonstrate here how consideration of relatedness to the person of interest can be incorporated into a LR calculation and how the same calculation can be used for familial searches of complex mixtures. We provide a general formula that can be used in semi or fully automated methods of calculation and demonstrate their use by working through an example.

KW - Continuous model

KW - DNA profile interpretation

KW - Likelihood ratio

KW - Mixtures

KW - Relatives

KW - STRmix

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DO - 10.1016/j.fsigen.2014.08.015

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EP - 263

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

SN - 1872-4973

ER -

Considering relatives when assessing the evidential strength of mixed DNA profiles

Abstract

Keywords

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