Content and turnover of noradrenaline in spinal cord and cerebellum of spontaneously hypertensive and stroke-prone rats

P. R.C. Howe, M. J. West, J. C. Provis, J. P. Chalmers

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    22 Citations (Scopus)

    Abstract

    The concentration of noradrenaline was measured in various regions of the brain and spinal cord of spontaneously hypertensive rats, stroke-prone spontaneously hypertensive rats and normotensive Wistar/Kyoto controls. Elevated noradrenaline levels were consistently found in the pons, cerebellum and spinal cord of the two hypertensive strains. These changes occurred both in young rats, during the early development of hypertension, and in mature rats, after establishment of the hypertension. The increaseses of cerebellar and spinal noradrenaline in mature stroke-prone rats could not be reversed by lowering blood pressure with hydralazine. The increased noradrenaline concentrations were not accompanied by increased tyrosine hydroxylase activity in the hypertensive rats. However, comparisons of noradrenaline turnover made using the catecholamine synthesis inhibitor, α-methyltyrosine, indicate an increased turnover of spinal noradrenaline in both hypertensive strains after establishment of hypertension. The results suggest that the activity of spinal noradrenergic nerves is augmented in genetically hypertensive animals.

    Original languageEnglish
    Pages (from-to)123-129
    Number of pages7
    JournalEuropean Journal of Pharmacology
    Volume73
    Issue number2-3
    DOIs
    Publication statusPublished - 17 Jul 1981

    Keywords

    • Genetic hypertension
    • Noradrenaline disappearance rate
    • Spontaneously hypertensive rat
    • Stroke-prone rat
    • Tyrosine hydroxylase activity
    • α-Methyltyrosine

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