Continuous flow vortex fluidic synthesis of silica xerogel as a delivery vehicle for curcumin

Chee Ling Tong, Uwe Stroeher, Melissa Brown, Colin Raston

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Sol-gel synthesis of silica xerogel at room temperature is effective using a vortex fluidic device operating under scalable continuous flow conditions, using only tetramethyl orthosilicate as the silica precursor and deionized water. The gelation time of the hydrogel can be as short as 3.5 hours depending on the concentration of the silica. This process is also effective in incorporating preformed sub-micron particles of curcumin, as an effective vehicle for bioavailability of this compound, which was shown by antimicrobial activity against Staphylococcus aureus.

    Original languageEnglish
    Pages (from-to)7953-7958
    Number of pages6
    JournalRSC Advances
    Volume5
    Issue number11
    DOIs
    Publication statusPublished - 2015

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