Contributions of ON and OFF pathways to emmetropization and form deprivation myopia in mice

Machelle T. Pardue, Ranjay Chakraborty, Hanna Park, Curran Sidhu, P. Michael Iuvone

Research output: Contribution to conferenceAbstractpeer-review

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The exact visual signals that modulate visually-driven eye growth are not known. ON and OFF pathways are essential for processing information about contrast sensitivity and illumination. In addition, ON pathway stimulation increases retinal dopamine levels, a key modulator of myopic eye growth. To determine the role of ON and OFF
retinal pathways in emmetropization and form-deprivation myopia, we examined mouse models with defects in these pathways.
Original languageEnglish
Number of pages1
Publication statusPublished - Sept 2015
Externally publishedYes
Event15th International Myopia Conference - Wenzhou, China
Duration: 23 Sept 201527 Sept 2015


Conference15th International Myopia Conference

Bibliographical note

© The Author(s). 2016 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver( applies to the data made available in this article, unless otherwise stated.


  • form deprivation myopia
  • mice
  • refractive development


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