Contributions of ON and OFF pathways to emmetropization and form deprivation myopia in mice

Machelle T. Pardue; Ranjay Chakraborty; Hanna Park; Curran Sidhu; P. Michael Iuvone

doi:10.1186/s40662-016-0057-3

Abstract

The exact visual signals that modulate visually-driven eye growth are not known. ON and OFF pathways are essential for processing information about contrast sensitivity and illumination. In addition, ON pathway stimulation increases retinal dopamine levels, a key modulator of myopic eye growth. To determine the role of ON and OFF
retinal pathways in emmetropization and form-deprivation myopia, we examined mouse models with defects in these pathways.

Original language	English
Pages	6-6
Number of pages	1
DOIs	https://doi.org/10.1186/s40662-016-0057-3
Publication status	Published - Sept 2015
Externally published	Yes
Event	15th International Myopia Conference - Wenzhou, China Duration: 23 Sept 2015 → 27 Sept 2015

Conference

Conference	15th International Myopia Conference
Country/Territory	China
City	Wenzhou
Period	23/09/15 → 27/09/15

Bibliographical note

© The Author(s). 2016 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Keywords

form deprivation myopia
mice
refractive development

Access to Document

10.1186/s40662-016-0057-3Licence: CC BY

Published versionFinal published version, 312 KBLicence: CC BY

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123376/Licence: CC BY

Cite this

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title = "Contributions of ON and OFF pathways to emmetropization and form deprivation myopia in mice",

abstract = "The exact visual signals that modulate visually-driven eye growth are not known. ON and OFF pathways are essential for processing information about contrast sensitivity and illumination. In addition, ON pathway stimulation increases retinal dopamine levels, a key modulator of myopic eye growth. To determine the role of ON and OFFretinal pathways in emmetropization and form-deprivation myopia, we examined mouse models with defects in these pathways.",

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author = "Pardue, {Machelle T.} and Ranjay Chakraborty and Hanna Park and Curran Sidhu and Iuvone, {P. Michael}",

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AU - Sidhu, Curran

AU - Iuvone, P. Michael

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N2 - The exact visual signals that modulate visually-driven eye growth are not known. ON and OFF pathways are essential for processing information about contrast sensitivity and illumination. In addition, ON pathway stimulation increases retinal dopamine levels, a key modulator of myopic eye growth. To determine the role of ON and OFFretinal pathways in emmetropization and form-deprivation myopia, we examined mouse models with defects in these pathways.

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KW - refractive development

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