Controlled Release of Levofloxacin Sandwiched between Two Plasma Polymerized Layers on a Solid Carrier

Krasimir Vasilev, Neil Poulter, Petr Martinek, Hans J. Griesser

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

Targeted delivery and controlled local release of drugs has a number of advantages over conventional systemic drug delivery approaches. Novel platforms for local delivery from solid drug carriers are needed to satisfy the requirements of various medical applications, in particular for the incorporation and release of hydrophilic drugs from a solid carrier material. We have utilized the plasma polymerization of n-heptylamine for the generation of two thin coated layers that serve two distinct purposes. First, an n-heptylamine plasma polymer layer is applied onto the surface of the solid carrier material in order to facilitate spreading of the drug, which is applied by solvent casting; levofloxacin in ethanol was used for this study. A second n-heptylamine plasma polymer coating then serves as a thin barrier coating to control the release. We show that the rate of release can be adjusted via the thickness of the plasma polymer overlayer. We also show that this modality of controlled release of levofloxacin completely inhibits Methicillin-resistant Staphylococcus aureus (MRSA) colonization and biofilm formation on and near the coated biomaterial surface.

Original languageEnglish
Pages (from-to)4831-4836
Number of pages6
JournalACS Applied Materials and Interfaces
Volume3
Issue number12
DOIs
Publication statusPublished - 28 Dec 2011
Externally publishedYes

Keywords

  • antibacterial surface
  • biofilm
  • controlled release
  • drug delivery
  • levofloxacin
  • n-heptylamine
  • plasma polymerization
  • Staphylococcus aureus

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