Copy Number Variant Study of Bipolar Disorder in Canadian and UK Populations Implicates Synaptic Genes

Abdul Noor, Anath Lionel, Sarah Cohen-Woods, Narges Moghimi, James Rucker, Alanna Fennell, Bhooma Thiruvahindrapuram, Liana Kaufman, Bryan Degagne, John Wei, Sagar Parikh, Pierandrea Muglia, Julia Forte, Stephen Scherer, James Kennedy, Wei Xu, Peter McGuffin, Anne Farmer, John Strauss, John Vincent

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    37 Citations (Scopus)

    Abstract

    Genome-wide single nucleotide polymorphism (SNP) data from 936 bipolar disorder (BD) individuals and 940 psychiatrically healthy comparison individuals of North European descent were analyzed for copy number variation (CNV). Using multiple CNV calling algorithms, and validating using in vitro molecular analyses, we identified CNVs implicating several candidate genes that encode synaptic proteins, such as DLG1, DLG2, DPP6, NRXN1, NRXN2, NRXN3, SHANK2, and EPHA5, as well as the neuronal splicing regulator RBFOX1 (A2BP1), and neuronal cell adhesion molecule CHL1. We have also identified recurrent CNVs on 15q13.3 and 16p11.2-regions previously reported as risk loci for neuropsychiatric disorders. In addition, we performed CNV analysis of individuals from 215 BD trios and identified de novo CNVs involving the NRXN1 and DRD5 genes. Our study provides further evidence of the occasional involvement of genomic mutations in the etiology of BD, however, there is no evidence of an increased burden of CNVs in BD. Further, the identification of CNVs at multiple members of the neurexin gene family in BD individuals, supports the role of synaptic disruption in the etiology of BD.

    Original languageEnglish
    Pages (from-to)303-313
    Number of pages11
    JournalAmerican Journal of Medical Genetics Part A
    Volume165B
    Issue number4
    DOIs
    Publication statusPublished - 2014

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  • Cite this

    Noor, A., Lionel, A., Cohen-Woods, S., Moghimi, N., Rucker, J., Fennell, A., Thiruvahindrapuram, B., Kaufman, L., Degagne, B., Wei, J., Parikh, S., Muglia, P., Forte, J., Scherer, S., Kennedy, J., Xu, W., McGuffin, P., Farmer, A., Strauss, J., & Vincent, J. (2014). Copy Number Variant Study of Bipolar Disorder in Canadian and UK Populations Implicates Synaptic Genes. American Journal of Medical Genetics Part A, 165B(4), 303-313. https://doi.org/10.1002/ajmg.b.32232