Corneal cells expressing active agents and methods of use thereof

Keryn Williams; Douglas Coster; Sonja Klebe

Corneal cells expressing active agents and methods of use thereof

Keryn Williams (Inventor), Douglas Coster (Inventor), Sonja Klebe (Inventor)

Research output: Patent

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Abstract

The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and allo-transplantation utilising the modified corneal tissue. The method of modifying cells of corneal tissue to express an active agent involves exposing harvested corneal tissue to an effective concentration for transfection of an expression vector which comprises a nucleotide sequence encoding for the active agent for a period sufficient to allow infection, such that cells of the corneal tissue will express the active agent.

Original language	English
Patent number	US7396528B2
Filing date	30/01/06
Publication status	Published - 8 Jul 2008

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US7396528Final published version, 2.15 MBLicence: Other

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title = "Corneal cells expressing active agents and methods of use thereof",

abstract = "The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and allo-transplantation utilising the modified corneal tissue. The method of modifying cells of corneal tissue to express an active agent involves exposing harvested corneal tissue to an effective concentration for transfection of an expression vector which comprises a nucleotide sequence encoding for the active agent for a period sufficient to allow infection, such that cells of the corneal tissue will express the active agent.",

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AU - Coster, Douglas

AU - Klebe, Sonja

PY - 2008/7/8

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N2 - The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and allo-transplantation utilising the modified corneal tissue. The method of modifying cells of corneal tissue to express an active agent involves exposing harvested corneal tissue to an effective concentration for transfection of an expression vector which comprises a nucleotide sequence encoding for the active agent for a period sufficient to allow infection, such that cells of the corneal tissue will express the active agent.

AB - The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and allo-transplantation utilising the modified corneal tissue. The method of modifying cells of corneal tissue to express an active agent involves exposing harvested corneal tissue to an effective concentration for transfection of an expression vector which comprises a nucleotide sequence encoding for the active agent for a period sufficient to allow infection, such that cells of the corneal tissue will express the active agent.

M3 - Patent

M1 - US7396528B2

Y2 - 2006/01/30

PB - United States Patent and Trademark Office

ER -

Corneal cells expressing active agents and methods of use thereof

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