Cortical excitability and neurology: Insights into the pathophysiology

Radwa, A. B. Badawy, Tobias Loetscher, Richard Macdonell, Amy Brodtmann

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Abstract

    Transcranial magnetic stimulation (TMS) is a technique developed to non-invasively investigate the integrity of human motor corticospinal tracts. Over the last three decades, the use of stimulation paradigms including single-pulse TMS, paired-pulse TMS, repetitive TMS, and integration with EEG and functional imaging have been developed to facilitate measurement of cortical excitability. Through the use of these protocols, TMS has evolved into an excellent tool for measuring cortical excitability. TMS has high sensitivity in detecting subtle changes in cortical excitability, and therefore it is also a good measure of disturbances associated with brain disorders. In this review, we appraise the current literature on cortical excitability studies using TMS in neurological disorders. We begin with a brief overview of current TMS measures and then show how these have added to our understanding of the underlying mechanisms of brain disorders.

    Original languageEnglish
    Pages (from-to)131-145
    Number of pages15
    JournalFunctional Neurology
    Volume27
    Issue number3
    Publication statusPublished - Jul 2012

    Keywords

    • Cortical excitability
    • Neurological disorders
    • Transcranial magnetic stimulation

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  • Cite this

    Badawy, R. A. B., Loetscher, T., Macdonell, R., & Brodtmann, A. (2012). Cortical excitability and neurology: Insights into the pathophysiology. Functional Neurology, 27(3), 131-145.