Cortisol does not inhibit prednisolone clearance.

PJ Meffin; BC Sallustio; YJ Purdie; RA Robson; LM Wing; PM Brooks

doi:10.1111/j.1365-2125.1985.tb05087.x

Cortisol does not inhibit prednisolone clearance.

PJ Meffin, BC Sallustio, YJ Purdie, RA Robson, LM Wing, PM Brooks

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Abstract

The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10‐fold higher than endogenous levels. The clearance and steady‐state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co‐ administration. 1985 The British Pharmacological Society

Original language	English
Pages (from-to)	414-416
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2125.1985.tb05087.x
Publication status	Published - Oct 1985

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10.1111/j.1365-2125.1985.tb05087.x

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title = "Cortisol does not inhibit prednisolone clearance.",

abstract = "The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10‐fold higher than endogenous levels. The clearance and steady‐state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co‐ administration. 1985 The British Pharmacological Society",

author = "PJ Meffin and BC Sallustio and YJ Purdie and RA Robson and LM Wing and PM Brooks",

year = "1985",

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AU - Meffin, PJ

AU - Sallustio, BC

AU - Purdie, YJ

AU - Robson, RA

AU - Wing, LM

AU - Brooks, PM

PY - 1985/10

Y1 - 1985/10

N2 - The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10‐fold higher than endogenous levels. The clearance and steady‐state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co‐ administration. 1985 The British Pharmacological Society

AB - The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10‐fold higher than endogenous levels. The clearance and steady‐state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co‐ administration. 1985 The British Pharmacological Society

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AN - SCOPUS:0022413060

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JF - British Journal of Clinical Pharmacology

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ER -

Cortisol does not inhibit prednisolone clearance.

Abstract

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