Cortisol does not inhibit prednisolone clearance.

PJ Meffin, BC Sallustio, YJ Purdie, RA Robson, LM Wing, PM Brooks

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10‐fold higher than endogenous levels. The clearance and steady‐state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co‐ administration. 1985 The British Pharmacological Society

    Original languageEnglish
    Pages (from-to)414-416
    Number of pages3
    JournalBritish Journal of Clinical Pharmacology
    Volume20
    Issue number4
    DOIs
    Publication statusPublished - Oct 1985

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