Cortisone and cortisol in maternal and fetal blood and in amniotic fluid during the final ten days of gestation in the rabbit

Heather A. Barr, Moira A. Lugg, Terence E. Nicholas

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    We have used instant thin-layer chromatography and radioimmunoassay to measure the concentrations of total cortisone (E) and cortisol (F) in the fetal and maternal compartments of the rabbit. The concentration of F in fetal blood increased markedly at day 25, this is just prior to the rapid increase in the surfactant phospholipids in lung tissue in this species. This increase coincided with a peak in the concentration of E and F in the maternal blood and may reflect the maternal levels. There was no ‘surge’ in the concentration of total F in fetal blood at term. The concentration of E in fetal blood varied between 5 and 15 ng/ml during this last stage of gestation, hence providing ready substrate for the 11β-reductase present in lung and other tissues. The concentration of E and F in maternal blood was significantly higher and more variable than that in blood from nonpregnant female rabbits, and there was a pronounced peak in concentration at day 30 (term: 31 days). The concentrations of both E and F in amniotic fluid were lower than those in either maternal or fetal blood until day 30 when the concentration of F increased fivefold to 19.2 ± 2.58 (mean ± SEM of 6 samples).

    Original languageEnglish
    Pages (from-to)214-220
    Number of pages7
    JournalNeonatology
    Volume38
    Issue number3-4
    DOIs
    Publication statusPublished - 1 Jan 1980

    Keywords

    • Amniotic fluid
    • Corticoids
    • Fetus
    • Pregnancy
    • Rabbit

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