Crosstalk between mTor Complexes

Jianling Xie, Christopher G. Proud

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.

Original languageEnglish
Pages (from-to)1263-1265
Number of pages3
JournalNature Cell Biology
Issue number11
Publication statusPublished - Nov 2013
Externally publishedYes


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