CSF Brain-Reactive Autoantibodies are Elevated in Patients with Viral Encephalitis

Zhong Yuan Yu, Jian Hong Wang, Wei Wei Li, Ye Ran Wang, Noralyn B. Mañucat-Tan, Jun Wang, Ju Wang, Gao Yu Cui, Jie Xiang Pan, Shui Xian Zhang, Zu Juan Liu, Liang Tan, Yu Hui Liu

Research output: Contribution to journalLetter

Abstract

Brain-reactive autoantibodies are thought to play an important role in mediating disorders of the central nervous system (CNS). These antibodies direct the processes underlying several diseases, such as multiple sclerosis (MS), neuromyelitis optica (NMO), and neuropsychiatric systemic lupus erythematosus [1,2,3]. In infectious diseases of the CNS, the pathogen itself is regarded to play a major role in the pathogenesis [4]. In recent years, post-viral autoimmune reactions have been identified to be critical factors that influence the pathogenesis [5, 6]. The best understood example is anti-NMDAR (N-methyl-d-aspartate receptor) encephalitis [7], which is commonly caused by viral infections, especially by herpes simplex virus (HSV) infection.
Original languageEnglish
Pages (from-to)942-946
Number of pages5
JournalNeuroscience Bulletin
Volume36
Issue number8
Early online date30 Apr 2020
DOIs
Publication statusPublished - 1 Aug 2020
Externally publishedYes

Keywords

  • brain-reactive autoantibodies
  • Autoantibodies
  • viral encephalitis
  • Central Nervous System

Fingerprint Dive into the research topics of 'CSF Brain-Reactive Autoantibodies are Elevated in Patients with Viral Encephalitis'. Together they form a unique fingerprint.

  • Cite this

    Yu, Z. Y., Wang, J. H., Li, W. W., Wang, Y. R., Mañucat-Tan, N. B., Wang, J., Wang, J., Cui, G. Y., Pan, J. X., Zhang, S. X., Liu, Z. J., Tan, L., & Liu, Y. H. (2020). CSF Brain-Reactive Autoantibodies are Elevated in Patients with Viral Encephalitis. Neuroscience Bulletin, 36(8), 942-946. https://doi.org/10.1007/s12264-020-00503-9