Current and future therapeutic prokinetic therapy to improve enteral feed intolerance in the ICU patient.

Robert Fraser, Laura Bryant

    Research output: Contribution to journalReview articlepeer-review

    38 Citations (Scopus)

    Abstract

    Malnutrition is associated with poor outcomes in critically ill patients, and providing enteral feeding to those who cannot eat is considered best practice. Enteral feeding is often unsuccessful when there is delayed gastric emptying. Recent research has given additional insight into the mechanisms underlying delayed gastric emptying. Pharmacological strategies to improve the success of feeding include prokinetic drugs such as metoclopramide and erythromycin alone or in combination. When drug treatment fails, either parenteral nutrition or direct small intestinal feeding is indicated. Simpler methods to access the duodenum and distal small bowel for feed delivery are under investigation. This review summarizes current understanding of the mechanisms underlying enteral feeding intolerance in critical illness, together with the evidence for current treatment practices. Areas requiring further research are also described. (Nutr Clin Pract. 2010;25:26-31).

    Original languageEnglish
    Pages (from-to)26-31
    Number of pages6
    JournalNutrition in Clinical Practice
    Volume25
    Issue number1
    DOIs
    Publication statusPublished - Feb 2010

    Keywords

    • Critical illness
    • Enteral nutrition
    • Gastrointestinal motility

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