Current concepts on diagnosis, autoantibodies and therapy in Sjögren's syndrome

Roland Jonsson, Hans-Jacob Haga, Tom. P. Gordon

    Research output: Contribution to journalReview articlepeer-review

    98 Citations (Scopus)

    Abstract

    Sjögren's syndrome is a chronic autoimmune and rheumatic disorder. Most patients have mild to moderate complaints and this may explain the great discrepancy in prevalence found in population studies compared to studies performed in the clinic. However, there is no straightforward and simple diagnostic test for Sjögren's syndrome, although several classification criteria have been designed. Initiatives have been taken to propose a new set of classification criteria in a joint effort by research groups in Europe and USA. A large number of autoantibodies have been reported in Sjögren's syndrome where, in some cases, the antibodies are correlated with the extent and severity of disease. The finding of serum autoantibodies directed against the muscarinic M3 receptor is an important advance in understanding the pathogenesis of not only the impaired glandular function but also associated features of autonomic dysfunction in some patients. The treatment of primary Sjögren's syndrome is still mainly symptomatic.

    Original languageEnglish
    Pages (from-to)341-348
    Number of pages8
    JournalScandinavian Journal of Rheumatology
    Volume29
    Issue number6
    DOIs
    Publication statusPublished - 1 Dec 2000

    Keywords

    • Autoantibodies
    • Diagnosis
    • Sjögren's syndrome
    • Therapy

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