Current opinion on optimal systemic treatment for metastatic colorectal cancer: Outcome of the ACTG/AGITG expert meeting ECCO 2013

Timothy Price, Eva Segelov, Matthew Burge, Daniel Haller, Niall Tebbutt, Christos Karapetis, C. Punt, Nick Pavlakis, Dirk Arnold, Peter Gibbs, Jeremy Shapiro

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    The treatment of metastatic colorectal cancer has evolved greatly in the last 15 years, involving combined chemotherapy protocols and, in more recent times, new biologic agents. Clinical benefit from the use of targeted therapy with bevacizumab, aflibercept, cetuximab, panitumumab and regorafenib in the treatment of metastatic colorectal cancer is now well established with median overall survival accepted as over 24 months, and with super selection for extended RAS patients higher again. The optimal timing of treatment options requires careful consideration of predictive biomarkers, and importantly the potential for interactions, to derive the maximal benefit. A group of colorectal subspecialty medical oncologists from Australia, the USA, the Netherlands and Germany met during ECCO 2013 to discuss current practice. Subsequent new data from the American Society of Clinical Oncology were also reviewed. This article reviews the evidence discussed in support of modern treatments for colorectal cancer and the decision-making behind the treatment choices, with their benefits and risks.

    Original languageEnglish
    Pages (from-to)1477-1493
    Number of pages17
    JournalExpert Review of Anticancer Therapy
    Volume14
    Issue number12
    DOIs
    Publication statusPublished - 2014

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  • Cite this

    Price, T., Segelov, E., Burge, M., Haller, D., Tebbutt, N., Karapetis, C., Punt, C., Pavlakis, N., Arnold, D., Gibbs, P., & Shapiro, J. (2014). Current opinion on optimal systemic treatment for metastatic colorectal cancer: Outcome of the ACTG/AGITG expert meeting ECCO 2013. Expert Review of Anticancer Therapy, 14(12), 1477-1493. https://doi.org/10.1586/14737140.2014.949678