Cutaneous vascular bed is not involved in arterial pressure changes elicited by increasing or decreasing the activity of inhibitory vasomotor neurons in caudal ventrolateral medulla in rabbits

W. W. Blessing, E. Nalivaiko

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    We determined whether caudal ventrolateral medulla (CVLM) vasodepressor neurons tonically inhibit vasomotor tone in the ear in anesthetized rabbits. Injection of L-glutamate (10 nmol in 100 nl) into the CVLM decreased arterial pressure and increased superior mesenteric conductance. Ear conductance decreased (0.43 ± 0.06 to 0.33 ± 0.05 cm s-1 per mmHg, n = 15 injections, 12 rabbits, P < 0.01). Conversely, bilateral injection of γ-aminobutyric acid (100 nmol in 100 nl) increased arterial pressure and decreased superior mesenteric conductance. At the same time ear conductance increased (0.39 ± 09 to 0.48 ± 0.27 cm s-1 per mmHg, n = 8 injections, eight rabbits, P < 0.05). Results suggest that ear vessels are not tonically inhibited by the CVLM vasodepressor neurons. Presympathetic motoneurons regulating cutaneous flow may be excited, rather than inhibited, by the CVLM neurons. (C) 2000 Elsevier Science Ireland Ltd.

    Original languageEnglish
    Pages (from-to)141-144
    Number of pages4
    JournalNeuroscience letters
    Volume290
    Issue number2
    DOIs
    Publication statusPublished - 25 Aug 2000

    Keywords

    • Arterial pressure
    • Caudal ventrolateral medulla
    • Vasomotor neurons

    Fingerprint Dive into the research topics of 'Cutaneous vascular bed is not involved in arterial pressure changes elicited by increasing or decreasing the activity of inhibitory vasomotor neurons in caudal ventrolateral medulla in rabbits'. Together they form a unique fingerprint.

    Cite this