Cyclin-dependent Kinase E1 (CDKE1) Provides a Cellular Switch in Plants between Growth and Stress Responses

Sophia Ng, Estelle Giraud, Owen Duncan, Simon Law, Yan Wang, Lin Xu, Reena Narsai, Chris Carrie, Hayden Walker, David Day, Nicolás Blanco, Åsa Strand, James Whelan, Aneta Ivanova

    Research output: Contribution to journalArticle

    78 Citations (Scopus)

    Abstract

    Background: Mitochondria send signals to the nucleus to modulate gene expression when mitochondrial function is perturbed. Results: Cyclin-dependent kinase E1 (CDKE1) was identified as an essential component in regulation of responses to perturbation of mitochondrial electron transport. Conclusion: Mitochondrial regulation is integrated with growth, energy, and other cellular stress signaling pathways. Significance: The identification of a molecular link between mitochondrial retrograde regulation and growth and stress signaling pathways.

    Original languageEnglish
    Pages (from-to)3449-3459
    Number of pages11
    JournalJournal of Biological Chemistry
    Volume288
    Issue number5
    DOIs
    Publication statusPublished - 2013

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  • Cite this

    Ng, S., Giraud, E., Duncan, O., Law, S., Wang, Y., Xu, L., Narsai, R., Carrie, C., Walker, H., Day, D., Blanco, N., Strand, Å., Whelan, J., & Ivanova, A. (2013). Cyclin-dependent Kinase E1 (CDKE1) Provides a Cellular Switch in Plants between Growth and Stress Responses. Journal of Biological Chemistry, 288(5), 3449-3459. https://doi.org/10.1074/jbc.M112.416727