Cyclin-dependent Kinase E1 (CDKE1) Provides a Cellular Switch in Plants between Growth and Stress Responses

Sophia Ng; Estelle Giraud; Owen Duncan; Simon Law; Yan Wang; Lin Xu; Reena Narsai; Chris Carrie; Hayden Walker; David Day; Nicolás Blanco; Åsa Strand; James Whelan; Aneta Ivanova

doi:10.1074/jbc.M112.416727

Cyclin-dependent Kinase E1 (CDKE1) Provides a Cellular Switch in Plants between Growth and Stress Responses

Sophia Ng, Estelle Giraud, Owen Duncan, Simon Law, Yan Wang, Lin Xu, Reena Narsai, Chris Carrie, Hayden Walker, David Day, Nicolás Blanco, Åsa Strand, James Whelan, Aneta Ivanova

Research output: Contribution to journal › Article

78 Citations (Scopus)

Abstract

Background: Mitochondria send signals to the nucleus to modulate gene expression when mitochondrial function is perturbed. Results: Cyclin-dependent kinase E1 (CDKE1) was identified as an essential component in regulation of responses to perturbation of mitochondrial electron transport. Conclusion: Mitochondrial regulation is integrated with growth, energy, and other cellular stress signaling pathways. Significance: The identification of a molecular link between mitochondrial retrograde regulation and growth and stress signaling pathways.

Original language	English
Pages (from-to)	3449-3459
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	5
DOIs	https://doi.org/10.1074/jbc.M112.416727
Publication status	Published - 2013

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Ng, S., Giraud, E., Duncan, O., Law, S., Wang, Y., Xu, L., Narsai, R., Carrie, C., Walker, H., Day, D., Blanco, N., Strand, Å., Whelan, J., & Ivanova, A. (2013). Cyclin-dependent Kinase E1 (CDKE1) Provides a Cellular Switch in Plants between Growth and Stress Responses. Journal of Biological Chemistry, 288(5), 3449-3459. https://doi.org/10.1074/jbc.M112.416727

Ng, Sophia ; Giraud, Estelle ; Duncan, Owen ; Law, Simon ; Wang, Yan ; Xu, Lin ; Narsai, Reena ; Carrie, Chris ; Walker, Hayden ; Day, David ; Blanco, Nicolás ; Strand, Åsa ; Whelan, James ; Ivanova, Aneta. / Cyclin-dependent Kinase E1 (CDKE1) Provides a Cellular Switch in Plants between Growth and Stress Responses. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 5. pp. 3449-3459.

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abstract = "Background: Mitochondria send signals to the nucleus to modulate gene expression when mitochondrial function is perturbed. Results: Cyclin-dependent kinase E1 (CDKE1) was identified as an essential component in regulation of responses to perturbation of mitochondrial electron transport. Conclusion: Mitochondrial regulation is integrated with growth, energy, and other cellular stress signaling pathways. Significance: The identification of a molecular link between mitochondrial retrograde regulation and growth and stress signaling pathways.",

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Cyclin-dependent Kinase E1 (CDKE1) Provides a Cellular Switch in Plants between Growth and Stress Responses. / Ng, Sophia; Giraud, Estelle; Duncan, Owen; Law, Simon; Wang, Yan; Xu, Lin; Narsai, Reena; Carrie, Chris; Walker, Hayden; Day, David; Blanco, Nicolás; Strand, Åsa; Whelan, James; Ivanova, Aneta.

In: Journal of Biological Chemistry, Vol. 288, No. 5, 2013, p. 3449-3459.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Cyclin-dependent Kinase E1 (CDKE1) Provides a Cellular Switch in Plants between Growth and Stress Responses

AU - Ng, Sophia

AU - Giraud, Estelle

AU - Duncan, Owen

AU - Law, Simon

AU - Wang, Yan

AU - Xu, Lin

AU - Narsai, Reena

AU - Carrie, Chris

AU - Walker, Hayden

AU - Day, David

AU - Blanco, Nicolás

AU - Strand, Åsa

AU - Whelan, James

AU - Ivanova, Aneta

PY - 2013

Y1 - 2013

N2 - Background: Mitochondria send signals to the nucleus to modulate gene expression when mitochondrial function is perturbed. Results: Cyclin-dependent kinase E1 (CDKE1) was identified as an essential component in regulation of responses to perturbation of mitochondrial electron transport. Conclusion: Mitochondrial regulation is integrated with growth, energy, and other cellular stress signaling pathways. Significance: The identification of a molecular link between mitochondrial retrograde regulation and growth and stress signaling pathways.

AB - Background: Mitochondria send signals to the nucleus to modulate gene expression when mitochondrial function is perturbed. Results: Cyclin-dependent kinase E1 (CDKE1) was identified as an essential component in regulation of responses to perturbation of mitochondrial electron transport. Conclusion: Mitochondrial regulation is integrated with growth, energy, and other cellular stress signaling pathways. Significance: The identification of a molecular link between mitochondrial retrograde regulation and growth and stress signaling pathways.

U2 - 10.1074/jbc.M112.416727

DO - 10.1074/jbc.M112.416727

M3 - Article

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SP - 3449

EP - 3459

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 1083-351X

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