Abstract
Background: Mitochondria send signals to the nucleus to modulate gene expression when mitochondrial function is perturbed. Results: Cyclin-dependent kinase E1 (CDKE1) was identified as an essential component in regulation of responses to perturbation of mitochondrial electron transport. Conclusion: Mitochondrial regulation is integrated with growth, energy, and other cellular stress signaling pathways. Significance: The identification of a molecular link between mitochondrial retrograde regulation and growth and stress signaling pathways.
Original language | English |
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Pages (from-to) | 3449-3459 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Feb 2013 |