Cytochrome P450 2. Pharmacogenetics

Inter‐individual variability in drug metabolism results from the influence of a myriad of factors including genetic factors and concurrent drug therapy. Advances in recombinant DNA technology have greatly enhanced our understanding of the extent of genetic variation in the P450 superfamily, clarifying the molecular basis of many clinically observed variations in drug response. This second article in the cytochrome P450 series describes our current understanding of genetic variability in the major drug‐metabolising P450s, the nomenclature used to describe variant P450 genes, and the clinical significance of such variability.