Cytochrome P450: 3. Clinically significant drug interactions

Recent advances in cytochrome P450 research have provided insights into the precise human cytochrome P450 complement, the role of individual P450 enzymes in drug metabolism and the various factors modulating P450 activity. Resulting from these advances is a clearer understanding of many established drug-drug and drug-food interactions, and an enhanced capacity to predict interactions likely to occur with newly introduced drugs. This final article in the three-part cytochrome P450 series describes our current understanding of drug interactions involving cytochrome P450 enzymes and highlights several clinically important examples.