Dapagliflozin Induced Acute Tubulo-Interstitial Nephritis:: A Case Report and Literature Review

Nida Saleem; Saima Bashir; Syed Nayer Mahmud; Muhammad Haneef

doi:10.12691/ajmcr-9-12-17

Dapagliflozin Induced Acute Tubulo-Interstitial Nephritis: A Case Report and Literature Review

Nida Saleem, Saima Bashir, Syed Nayer Mahmud, Muhammad Haneef

Research output: Contribution to journal › Article › peer-review

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Abstract

We report a case of an elderly male patient, who presented with acute kidney injury on background of diabetic nephropathy, secondary to dapagliflozin induced acute tubulo-interstitial nephritis requiring hemodialysis sessions. Histopathological findings are consistent with moderate tubulo-interstitial inflammation with mixed lymphocytic and eosinophilic inflammatory deposits. The patient responded well to cessation of causative medication and upon initiation of high dose steroids. The direct cause and effect relationship between dapagliflozin initiation and development of acute tubulo-interstitial nephritis is indicative of dapagliflozin being responsible for marked renal deterioration, as seen in this patient.

Original language	English
Pages (from-to)	725-728
Number of pages	4
Journal	American Journal of Medical Case Reports
Volume	9
Issue number	12
DOIs	https://doi.org/10.12691/ajmcr-9-12-17
Publication status	Published - Oct 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute interstitial nephritis (AIN)
Diabetes
dapagliflozin
SGLT2 inhibitors
acute kidney injury (AKI)

Access to Document

10.12691/ajmcr-9-12-17Licence: CC BY

Published versionFinal published version, 550 KBLicence: CC BY

Cite this

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title = "Dapagliflozin Induced Acute Tubulo-Interstitial Nephritis:: A Case Report and Literature Review",

abstract = "We report a case of an elderly male patient, who presented with acute kidney injury on background of diabetic nephropathy, secondary to dapagliflozin induced acute tubulo-interstitial nephritis requiring hemodialysis sessions. Histopathological findings are consistent with moderate tubulo-interstitial inflammation with mixed lymphocytic and eosinophilic inflammatory deposits. The patient responded well to cessation of causative medication and upon initiation of high dose steroids. The direct cause and effect relationship between dapagliflozin initiation and development of acute tubulo-interstitial nephritis is indicative of dapagliflozin being responsible for marked renal deterioration, as seen in this patient.",

keywords = "Acute interstitial nephritis (AIN), Diabetes, dapagliflozin, SGLT2 inhibitors, acute kidney injury (AKI)",

author = "Nida Saleem and Saima Bashir and Mahmud, {Syed Nayer} and Muhammad Haneef",

year = "2021",

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language = "English",

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journal = "American Journal of Medical Case Reports",

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AU - Bashir, Saima

AU - Mahmud, Syed Nayer

AU - Haneef, Muhammad

PY - 2021/10

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N2 - We report a case of an elderly male patient, who presented with acute kidney injury on background of diabetic nephropathy, secondary to dapagliflozin induced acute tubulo-interstitial nephritis requiring hemodialysis sessions. Histopathological findings are consistent with moderate tubulo-interstitial inflammation with mixed lymphocytic and eosinophilic inflammatory deposits. The patient responded well to cessation of causative medication and upon initiation of high dose steroids. The direct cause and effect relationship between dapagliflozin initiation and development of acute tubulo-interstitial nephritis is indicative of dapagliflozin being responsible for marked renal deterioration, as seen in this patient.

AB - We report a case of an elderly male patient, who presented with acute kidney injury on background of diabetic nephropathy, secondary to dapagliflozin induced acute tubulo-interstitial nephritis requiring hemodialysis sessions. Histopathological findings are consistent with moderate tubulo-interstitial inflammation with mixed lymphocytic and eosinophilic inflammatory deposits. The patient responded well to cessation of causative medication and upon initiation of high dose steroids. The direct cause and effect relationship between dapagliflozin initiation and development of acute tubulo-interstitial nephritis is indicative of dapagliflozin being responsible for marked renal deterioration, as seen in this patient.

KW - Acute interstitial nephritis (AIN)

KW - Diabetes

KW - dapagliflozin

KW - SGLT2 inhibitors

KW - acute kidney injury (AKI)

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EP - 728

JO - American Journal of Medical Case Reports

JF - American Journal of Medical Case Reports

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ER -