Dark Agouti rat model of chemotherapy-induced mucositis: Establishment and current state of the art

Barbara Vanhoecke, Emma Bateman, Bronwen Mayo, Eline Vanlancker, Andrea Stringer, Daniel Thorpe, Dorothy Keefe

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mucositis is a major oncological problem. The entire gastrointestinal and genitourinary tract and also other mucosal surfaces can be affected in recipients of radiotherapy, and/or chemotherapy. Major progress has been made in recent years in understanding the mechanisms of oral and small intestinal mucositis, which appears to be more prominent than colonic damage. This progress is largely due to the development of representative laboratory animal models of mucositis. This review focuses on the development and establishment of the Dark Agouti rat mammary adenocarcinoma model by the Mucositis Research Group of the University of Adelaide over the past 20 years to characterize the mechanisms underlying methotrexate-, 5-fluorouracil-, and irinotecan-induced mucositis. It also aims to summarize the results from studies using different animal model systems to identify new molecular and cellular markers of mucositis.

Original languageEnglish
Pages (from-to)725-741
Number of pages17
JournalExperimental Biology and Medicine
Volume240
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • 5-fluorouracil
  • chemotherapy
  • irinotecan
  • methotrexate
  • mucositis
  • Rat

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