@article{14e84d5a403a4f9d8c9feaad697c3880,
title = "Death in hospital following ICU discharge: insights from the LUNG SAFE study",
abstract = "Background: To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods: The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments ({\textquoteleft}treatment limitations{\textquoteright}), and the subpopulations with treatment limitations. Results: 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions: A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov NCT02010073.",
keywords = "Acute hypoxemic respiratory failure, Acute respiratory distress syndrome, Hospital survival, ICU discharge, LUNG SAFE",
author = "Fabiana Madotto and Bairbre McNicholas and Emanuele Rezoagli and T{\`a}i Pham and Laffey, {John G.} and Giacomo Bellani and {the LUNG SAFE Investigators and the ESICM Trials Group} and Antonio Pesenti and Laurent Brochard and Andres Esteban and Luciano Gattinoni and {van Haren}, Frank and Anders Larsson and McAuley, {Daniel F.} and Marco Ranieri and Gordon Rubenfeld and Thompson, {B. Taylor} and Hermann Wrigge and Slutsky, {Arthur S.} and Fernando Rios and Faruq, {Mohammad Omar} and T. Sottiaux and P. Depuydt and Lora, {Fredy S.} and Azevedo, {Luciano Cesar} and Eddy Fan and Guillermo Bugedo and Haibo Qiu and Marcos Gonzalez and Juan Silesky and Vladimir Cerny and Jonas Nielsen and Manuel Jibaja and Dimitrios Matamis and Ranero, {Jorge Luis} and Charles Gomersall and Pravin Amin and Hashemian, {S. M.} and Kevin Clarkson and Kiyoyasu Kurahashi and Younsuck Koh and Asisclo Villagomez and Zeggwagh, {Amine Ali} and Heunks, {Leo M.} and Laake, {Jon Henrik} and Waqar Kashif and Jorge Synclair and Palo, {Jose Emmanuel} and {do Vale Fernandes}, Antero and Dorel Sandesc and Yaasen Arabi and Vesna Bumbasierevic and Nicolas Nin and Lorente, {Jose A.} and Lise Piquilloud and Boonsong Patjanasoontorn and Fekri Abroug and Lia McNamee and Javier Hurtado and Ed Bajwa and Gabriel D{\'e}mpaire and Francois, {Guy M.} and Francesca Rabboni and Sara Conti and Hektor Sula and Lordian Nunci and Alma Cani and Alan Zazu and Christian Dellera and Insaurralde, {Carolina S.} and Alejandro, {Risso V.} and Julio Daldin and Mauricio Vinzio and Fernandez, {Ruben O.} and Cardonnet, {Luis P.} and Bettini, {Lisandro R.} and Bisso, {Mariano Carboni} and Osman, {Emilio M.} and Setten, {Mariano G.} and Pablo Lovazzano and Javier Alvarez and Veronica Villar and Pozo, {Norberto C.} and Nicolas Grubissich and Plotnikow, {Gustavo A.} and Vasquez, {Daniela N.} and Santiago Ilutovich and Norberto Tiribelli and Ariel Chena and Pellegrini, {Carlos A.} and Saenz, {Mar{\'i}a G.} and Elisa Estenssoro and Matias Brizuela and Hernan Gianinetto and Gomez, {Pablo E.} and Cerrato, {Valeria I.} and Bezzi, {Marco G.} and Borello, {Silvina A.} and Loiacono, {Flavia A.} and Fernandez, {Adriana M.} and Serena Knowles and Claire Reynolds and Inskip, {Deborah M.} and Miller, {Jennene J.} and Jing Kong and Christina Whitehead and Shailesh Bihari and Aylin Seven and Amanda Krstevski and Rodgers, {Helen J.} and Millar, {Rebecca T.} and Mckenna, {Toni E.} and Bailey, {Irene M.} and Hanlon, {Gabrielle C.} and Anders Aneman and Lynch, {Joan M.} and Raman Azad and John Neal and Woods, {Paul W.} and Roberts, {Brigit L.} and Kol, {Mark R.} and Wong, {Helen S.} and Riss, {Katharina C.} and Thomas Staudinger and Xavier Wittebole and Caroline Berghe and Bulpa, {Pierre A.} and Dive, {Alain M.} and Rik Verstraete and Herve Lebbinck and Pieter Depuydt and Joris Vermassen and Philippe Meersseman and Helga Ceunen and Rosa, {Jonas I.} and Beraldo, {Daniel O.} and Claudio Piras and Rampinelli, {Adenilton M.} and {Nassar Jnr}, {Antonio P} and Sergio Mataloun and Marcelo Moock and Thompson, {Marlus M.} and Gon{\c c}alves, {Claudio H.} and Ant{\^o}nio, {Ana Carolina P.} and Aline Ascoli and Biondi, {Rodrigo S.} and Fontenele, {Danielle C.} and Danielle Nobrega and Sales, {Vanessa M.} and Suresh Shindhe and Aiman, {Dk Maizatul} and Ismail, {BPg P.H.} and John Laffey and Francois Beloncle and Davies, {Kyle G.} and Rob Cirone and Venika Manoharan and Mehvish Ismail and Goligher, {Ewan C.} and Ferguson, {Niall D.} and Mandeep Jassal and Erin Nishikawa and Areej Javeed and Gerard Curley and Nuttapol Rittayamai and Matteo Parotto and Sangeeta Mehta and Jenny Knoll and Antoine Pronovost and Sergio Canestrini and Bruhn, {Alejandro R.} and Garcia, {Patricio H.} and Aliaga, {Felipe A.} and Far{\'i}as, {Pamela A.} and Yumha, {Jacob S.} and Ortiz, {Claudia A.} and Salas, {Javier E.} and Saez, {Alejandro A.} and Vega, {Luis D.} and Labarca, {Eduardo F.} and Martinez, {Felipe T.} and Carre{\~n}o, {Nicol{\'a}s G.} and Pilar Lora and Haitao Liu and Haibo Qiu and Ling Liu and Rui Tang and Xiaoming Luo and Youzhong An and Huiying Zhao and Yan Gao and Zhe Zhai and Ye, {Zheng L.} and Wei Wang and Wenwen Li and Qingdong Li and Ruiqiang Zheng and Wenkui Yu and Juanhong Shen and Xinyu Li and Tao Yu and Weihua Lu and Wu, {Ya Q.} and Huang, {Xiao B.} and Zhenyang He and Yuanhua Lu and Hui Han and Fan Zhang and Renhua Sun and Wang, {Hua X.} and Qin, {Shu H.} and Zhu, {Bao H.} and Jun Zhao and Jian Liu and Bin Li and Liu, {Jing L.} and Zhou, {Fa C.} and Li, {Qiong J.} and Zhang, {Xing Y.} and Zhou Li-Xin and Qiang Xin-Hua and Liangyan Jiang and Gao, {Yuan N.} and Zhao, {Xian Y.} and Li, {Yuan Y.} and Li, {Xiao L.} and Chunting Wang and Qingchun Yao and Rongguo Yu and Kai Chen and Huanzhang Shao and Bingyu Qin and Huang, {Qing Q.} and Zhu, {Wei H.} and Hang, {Ai Y.} and Hua, {Ma X.} and Yimin Li and Yonghao Xu and Di, {Yu D.} and Ling, {Long L.} and Qin, {Tie H.} and Wang, {Shou H.} and Junping Qin and Yi Han and Suming Zhou and Vargas, {Monica P.} and Vijayanand Palaniswamy and Dowling, {Anna T.}",
year = "2021",
month = apr,
day = "13",
doi = "10.1186/s13054-021-03465-0",
language = "English",
volume = "25",
journal = "Critical Care",
issn = "1364-8535",
publisher = "BioMed Central Ltd.",
number = "1",
}