Decreased Cloning of Lymphocytes from Elderly Individuals

A. CHRYSOSTOMOU, R. SESHADRI, A. A. MORLEY

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Limiting‐dilution cloning of human lymphocytes was used to study cloning and proliferation of lymphocytes in 10 young and 10 elderly individuals. The cloning efficiency for elderly individuals, 3.5%, was significantly lower than that for young individuals, 19.8%. Mixing experiments showed that this decrease was due to both a decrease in the frequency of the clone‐forming cells and a decrease in the interacting ability of the lymphocytes. Lymphocytes from elderly individuals which did form clones, however, proliferated at the same rate as did those from young individuals.

    Original languageEnglish
    Pages (from-to)293-296
    Number of pages4
    JournalScandinavian Journal of Immunology
    Volume19
    Issue number4
    DOIs
    Publication statusPublished - Apr 1984

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