Defining myocardial infarction in trials of people receiving hemodialysis: consensus report from the SONG-HD MI Expert Working group

Emma O'Lone; Fred S. Apple; James O. Burton; Fergus J. Caskey; Jonathan C. Craig; Christopher R. deFilippi; Derek Forfang; Karen A. Hicks; Vivekanand Jha; Kenneth W. Mahaffey; Patrick B. Mark; Patrick Rossignol; Nicole Scholes-Robertson; Allison Jaure; Andrea K. Viecelli; Angela Y. Wang; David C. Wheeler; David White; Wolfgang C. Winkelmayer; Charles A. Herzog

doi:10.1016/j.kint.2023.02.033

Defining myocardial infarction in trials of people receiving hemodialysis: consensus report from the SONG-HD MI Expert Working group

Emma O'Lone, Fred S. Apple, James O. Burton, Fergus J. Caskey, Jonathan C. Craig, Christopher R. deFilippi, Derek Forfang, Karen A. Hicks, Vivekanand Jha, Kenneth W. Mahaffey, Patrick B. Mark, Patrick Rossignol, Nicole Scholes-Robertson, Allison Jaure, Andrea K. Viecelli, Angela Y. Wang, David C. Wheeler, David White, Wolfgang C. Winkelmayer, Charles A. Herzog

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Cardiovascular disease is the leading cause of death in patients receiving hemodialysis. Currently, there is no standardized definition of myocardial infarction (MI) for patients receiving hemodialysis. Through an international consensus process MI was established as the core CVD measure for this population in clinical trials. The Standardised Outcomes in Nephrology Group—Hemodialysis (SONG-HD) initiative convened a multidisciplinary, international working group to address the definition of MI in this population. On the basis of current evidence, the working group recommends using the Fourth Universal Definition of Myocardial Infarction with specific caveats with regard to the interpretation of “ischemic symptoms” and performing a baseline 12-lead electrocardiogram to facilitate interpretation of acute changes on subsequent tracings. The working group does not recommend obtaining baseline cardiac troponin values, though does recommend obtaining serial cardiac biomarkers in settings where ischemia is suspected. The application of an evidence-based uniform definition should increase the reliability and accuracy of trial results.

Original language	English
Pages (from-to)	1028-1037
Number of pages	10
Journal	Kidney International
Volume	103
Issue number	6
Early online date	5 Apr 2023
DOIs	https://doi.org/10.1016/j.kint.2023.02.033
Publication status	Published - Jun 2023

Keywords

definition
hemodialysis
myocardial infarction
outcome
recommendations
trials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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O'Lone, E., Apple, F. S., Burton, J. O., Caskey, F. J., Craig, J. C., deFilippi, C. R., Forfang, D., Hicks, K. A., Jha, V., Mahaffey, K. W., Mark, P. B., Rossignol, P., Scholes-Robertson, N., Jaure, A., Viecelli, A. K., Wang, A. Y., Wheeler, D. C., White, D., Winkelmayer, W. C., & Herzog, C. A. (2023). Defining myocardial infarction in trials of people receiving hemodialysis: consensus report from the SONG-HD MI Expert Working group. Kidney International, 103(6), 1028-1037. https://doi.org/10.1016/j.kint.2023.02.033

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title = "Defining myocardial infarction in trials of people receiving hemodialysis: consensus report from the SONG-HD MI Expert Working group",

abstract = "Cardiovascular disease is the leading cause of death in patients receiving hemodialysis. Currently, there is no standardized definition of myocardial infarction (MI) for patients receiving hemodialysis. Through an international consensus process MI was established as the core CVD measure for this population in clinical trials. The Standardised Outcomes in Nephrology Group—Hemodialysis (SONG-HD) initiative convened a multidisciplinary, international working group to address the definition of MI in this population. On the basis of current evidence, the working group recommends using the Fourth Universal Definition of Myocardial Infarction with specific caveats with regard to the interpretation of “ischemic symptoms” and performing a baseline 12-lead electrocardiogram to facilitate interpretation of acute changes on subsequent tracings. The working group does not recommend obtaining baseline cardiac troponin values, though does recommend obtaining serial cardiac biomarkers in settings where ischemia is suspected. The application of an evidence-based uniform definition should increase the reliability and accuracy of trial results.",

keywords = "definition, hemodialysis, myocardial infarction, outcome, recommendations, trials",

author = "Emma O'Lone and Apple, {Fred S.} and Burton, {James O.} and Caskey, {Fergus J.} and Craig, {Jonathan C.} and deFilippi, {Christopher R.} and Derek Forfang and Hicks, {Karen A.} and Vivekanand Jha and Mahaffey, {Kenneth W.} and Mark, {Patrick B.} and Patrick Rossignol and Nicole Scholes-Robertson and Allison Jaure and Viecelli, {Andrea K.} and Wang, {Angela Y.} and Wheeler, {David C.} and David White and Winkelmayer, {Wolfgang C.} and Herzog, {Charles A.}",

year = "2023",

month = jun,

doi = "10.1016/j.kint.2023.02.033",

language = "English",

volume = "103",

pages = "1028--1037",

journal = "Kidney International",

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O'Lone, E, Apple, FS, Burton, JO, Caskey, FJ, Craig, JC, deFilippi, CR, Forfang, D, Hicks, KA, Jha, V, Mahaffey, KW, Mark, PB, Rossignol, P, Scholes-Robertson, N, Jaure, A, Viecelli, AK, Wang, AY, Wheeler, DC, White, D, Winkelmayer, WC & Herzog, CA 2023, 'Defining myocardial infarction in trials of people receiving hemodialysis: consensus report from the SONG-HD MI Expert Working group', Kidney International, vol. 103, no. 6, pp. 1028-1037. https://doi.org/10.1016/j.kint.2023.02.033

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T1 - Defining myocardial infarction in trials of people receiving hemodialysis

T2 - consensus report from the SONG-HD MI Expert Working group

AU - O'Lone, Emma

AU - Apple, Fred S.

AU - Burton, James O.

AU - Caskey, Fergus J.

AU - Craig, Jonathan C.

AU - deFilippi, Christopher R.

AU - Forfang, Derek

AU - Hicks, Karen A.

AU - Jha, Vivekanand

AU - Mahaffey, Kenneth W.

AU - Mark, Patrick B.

AU - Rossignol, Patrick

AU - Scholes-Robertson, Nicole

AU - Jaure, Allison

AU - Viecelli, Andrea K.

AU - Wang, Angela Y.

AU - Wheeler, David C.

AU - White, David

AU - Winkelmayer, Wolfgang C.

AU - Herzog, Charles A.

PY - 2023/6

Y1 - 2023/6

N2 - Cardiovascular disease is the leading cause of death in patients receiving hemodialysis. Currently, there is no standardized definition of myocardial infarction (MI) for patients receiving hemodialysis. Through an international consensus process MI was established as the core CVD measure for this population in clinical trials. The Standardised Outcomes in Nephrology Group—Hemodialysis (SONG-HD) initiative convened a multidisciplinary, international working group to address the definition of MI in this population. On the basis of current evidence, the working group recommends using the Fourth Universal Definition of Myocardial Infarction with specific caveats with regard to the interpretation of “ischemic symptoms” and performing a baseline 12-lead electrocardiogram to facilitate interpretation of acute changes on subsequent tracings. The working group does not recommend obtaining baseline cardiac troponin values, though does recommend obtaining serial cardiac biomarkers in settings where ischemia is suspected. The application of an evidence-based uniform definition should increase the reliability and accuracy of trial results.

AB - Cardiovascular disease is the leading cause of death in patients receiving hemodialysis. Currently, there is no standardized definition of myocardial infarction (MI) for patients receiving hemodialysis. Through an international consensus process MI was established as the core CVD measure for this population in clinical trials. The Standardised Outcomes in Nephrology Group—Hemodialysis (SONG-HD) initiative convened a multidisciplinary, international working group to address the definition of MI in this population. On the basis of current evidence, the working group recommends using the Fourth Universal Definition of Myocardial Infarction with specific caveats with regard to the interpretation of “ischemic symptoms” and performing a baseline 12-lead electrocardiogram to facilitate interpretation of acute changes on subsequent tracings. The working group does not recommend obtaining baseline cardiac troponin values, though does recommend obtaining serial cardiac biomarkers in settings where ischemia is suspected. The application of an evidence-based uniform definition should increase the reliability and accuracy of trial results.

KW - definition

KW - hemodialysis

KW - myocardial infarction

KW - outcome

KW - recommendations

KW - trials

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AN - SCOPUS:85153614287

SN - 0085-2538

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SP - 1028

EP - 1037

JO - Kidney International

JF - Kidney International

IS - 6

ER -

Defining myocardial infarction in trials of people receiving hemodialysis: consensus report from the SONG-HD MI Expert Working group

Abstract

Keywords

UN SDGs

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