Definition of Sporadic Early-Onset Invasive Solid Organ Cancers in Adults

Savio George Barreto; Irit Ben-Aharon; Cathy Eng; Shailesh V. Shrikhande; Bhawna Sirohi; Kjetil Søreide; Stephen J. Pandol

doi:10.1007/s40487-025-00405-8

Definition of Sporadic Early-Onset Invasive Solid Organ Cancers in Adults

Savio George Barreto, Irit Ben-Aharon, Cathy Eng, Shailesh V. Shrikhande, Bhawna Sirohi, Kjetil Søreide, Stephen J. Pandol

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Abstract

With a rising incidence globally, there is need to address a basic deficiency, namely, the lack of a clear definition of sporadic early-onset invasive solid organ cancers in adults. This manuscript discusses this need to have a unified understanding of what constitutes sporadic early-onset cancers in adults based on (epi)genetic, biological, and environmental influences with an aim to motivate clinicians and scientists to think about these cancers from a broader perspective when developing their own research programs.

Original language	English
Number of pages	9
Journal	Oncology and Therapy
DOIs	https://doi.org/10.1007/s40487-025-00405-8
Publication status	E-pub ahead of print - 24 Nov 2025

Keywords

Outcomes
Research
Young-onset
solid organ cancers

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10.1007/s40487-025-00405-8Licence: CC BY-NC

Published versionFinal published version, 339 KBLicence: CC BY-NC

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title = "Definition of Sporadic Early-Onset Invasive Solid Organ Cancers in Adults",

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T1 - Definition of Sporadic Early-Onset Invasive Solid Organ Cancers in Adults

AU - Barreto, Savio George

AU - Ben-Aharon, Irit

AU - Eng, Cathy

AU - Shrikhande, Shailesh V.

AU - Sirohi, Bhawna

AU - Søreide, Kjetil

AU - Pandol, Stephen J.

PY - 2025/11/24

Y1 - 2025/11/24

N2 - With a rising incidence globally, there is need to address a basic deficiency, namely, the lack of a clear definition of sporadic early-onset invasive solid organ cancers in adults. This manuscript discusses this need to have a unified understanding of what constitutes sporadic early-onset cancers in adults based on (epi)genetic, biological, and environmental influences with an aim to motivate clinicians and scientists to think about these cancers from a broader perspective when developing their own research programs.

AB - With a rising incidence globally, there is need to address a basic deficiency, namely, the lack of a clear definition of sporadic early-onset invasive solid organ cancers in adults. This manuscript discusses this need to have a unified understanding of what constitutes sporadic early-onset cancers in adults based on (epi)genetic, biological, and environmental influences with an aim to motivate clinicians and scientists to think about these cancers from a broader perspective when developing their own research programs.

KW - Outcomes

KW - Research

KW - Young-onset

KW - solid organ cancers

UR - http://www.scopus.com/inward/record.url?scp=105022788419&partnerID=8YFLogxK

UR - http://purl.org/au-research/grants/NHMRC/2021009

U2 - 10.1007/s40487-025-00405-8

DO - 10.1007/s40487-025-00405-8

M3 - Comment/debate

AN - SCOPUS:105022788419

SN - 2366-1070

JO - Oncology and Therapy

JF - Oncology and Therapy

ER -

Definition of Sporadic Early-Onset Invasive Solid Organ Cancers in Adults

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