Abstract
This study examined the effect of 1,3-butanediol on the selective loss of CA1 pyramidal neurons following a short period of near-complete forebrain ischemia. Injection of 55 mmol 1,3-butanediol/kg body weight at 24 h of recirculation and again at 36 h following 10 min of forebrain ischemia markedly reduced damage to CA1 neurons examined at 72 h of recirculation compared with that in saline-treated rats. Comparable treatment with ethanol did not cause significant protection. Neuronal loss was also not reduced by 1,3-butanediol treatment when the ischemic period was extended to 15 min or by single treatments at 24 h or 36 h following 10 min of ischemia. However, a single treatment 5 min after reversal of 10 min of ischemia was effective in ameliorating cell loss. The difference in effectiveness of 1,3-butanediol following 10 min and 15 min of ischemia is consistent with a number of previous studies, indicating that the processes leading to loss of CA1 neurons are modified when the ischemic period is extended. Previous findings that 1,3-butanediol reduced damage in other ischemia-susceptible neuronal subpopulations but not in CA1 neurons most likely reflected the longer period of ischemia which was used. The results of the present investigation demonstrate that administration of 1,3-butanediol offers a novel approach for interfering with post-ischemic loss of CA1 neurons following a brief ischemic period which is effective even when initiated after prolonged recirculation periods.
Original language | English |
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Pages (from-to) | 216-222 |
Number of pages | 7 |
Journal | Brain Research |
Volume | 662 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 31 Oct 1994 |
Bibliographical note
Funding Information:We thank Mr. E. Zaidan for his assistancein the collectiono f blood samplesf rom rats and ProfessorM . Berry and Mrs. L. Williams for providingt he analyses of 3-hydroxybutyraaten d acetoacetateT.h is work was supported by grants from the National Health and Medical Research Council, Flinders 2000 and the FIinders UniversityR esearchB udget.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
Keywords
- 1,3-Butanediol
- CA1
- Hippocampus
- Ischemia
- Ketone body
- Neuronal loss
- Protection