Demethylation of 3-O-methyldopa in the rat

J. P. Chalmers, G. H. Draffan, J. L. Reid, S. S. Thorgeirsson, D. S. Davies

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Following the intraperitoneal administration of L-3-O-14C-methyl-4-hydroxyphenylalanine (14C-3-o-methyldopa; 14C-OMD), to rats, 15-20% of the injected radioactivity appeared in the expired air as 14C-CO2 over a period of 3-4 days; 65% of the dose was excreted in the urine and 8% in the faeces. When the experiments were repeated in rats with biliary fistulae, 20% of the dose was excreted in the bile in the first 24 hours, and there was no longer any detectable 14C-CO2 in the expired air. These studies establish that 3-o-methyldopa is demethylated in rats in vivo and that the demethylation occurs mainly in the gut.

Original languageEnglish
Pages (from-to)1243-1251
Number of pages9
JournalLife Sciences
Volume10
Issue number21, Part 1
DOIs
Publication statusPublished - 1 Nov 1971
Externally publishedYes

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