Demethylation of 3-O-methyldopa in the rat

J. P. Chalmers; G. H. Draffan; J. L. Reid; S. S. Thorgeirsson; D. S. Davies

doi:10.1016/0024-3205(71)90294-3

Demethylation of 3-O-methyldopa in the rat

J. P. Chalmers
, G. H. Draffan
, J. L. Reid
, S. S. Thorgeirsson
, D. S. Davies

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Following the intraperitoneal administration of L-3-O-¹⁴C-methyl-4-hydroxyphenylalanine (¹⁴C-3-o-methyldopa; ¹⁴C-OMD), to rats, 15-20% of the injected radioactivity appeared in the expired air as ¹⁴C-CO2 over a period of 3-4 days; 65% of the dose was excreted in the urine and 8% in the faeces. When the experiments were repeated in rats with biliary fistulae, 20% of the dose was excreted in the bile in the first 24 hours, and there was no longer any detectable ¹⁴C-CO2 in the expired air. These studies establish that 3-o-methyldopa is demethylated in rats in vivo and that the demethylation occurs mainly in the gut.

Original language	English
Pages (from-to)	1243-1251
Number of pages	9
Journal	Life Sciences
Volume	10
Issue number	21, Part 1
DOIs	https://doi.org/10.1016/0024-3205(71)90294-3
Publication status	Published - 1 Nov 1971
Externally published	Yes

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@article{25ee35091d8e4775afcc072c5fc94c48,

title = "Demethylation of 3-O-methyldopa in the rat",

abstract = "Following the intraperitoneal administration of L-3-O-14C-methyl-4-hydroxyphenylalanine (14C-3-o-methyldopa; 14C-OMD), to rats, 15-20\% of the injected radioactivity appeared in the expired air as 14C-CO2 over a period of 3-4 days; 65\% of the dose was excreted in the urine and 8\% in the faeces. When the experiments were repeated in rats with biliary fistulae, 20\% of the dose was excreted in the bile in the first 24 hours, and there was no longer any detectable 14C-CO2 in the expired air. These studies establish that 3-o-methyldopa is demethylated in rats in vivo and that the demethylation occurs mainly in the gut.",

author = "Chalmers, \{J. P.\} and Draffan, \{G. H.\} and Reid, \{J. L.\} and Thorgeirsson, \{S. S.\} and Davies, \{D. S.\}",

year = "1971",

month = nov,

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doi = "10.1016/0024-3205(71)90294-3",

language = "English",

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journal = "Life Sciences",

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number = "21, Part 1",

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TY - JOUR

T1 - Demethylation of 3-O-methyldopa in the rat

AU - Chalmers, J. P.

AU - Draffan, G. H.

AU - Reid, J. L.

AU - Thorgeirsson, S. S.

AU - Davies, D. S.

PY - 1971/11/1

Y1 - 1971/11/1

N2 - Following the intraperitoneal administration of L-3-O-14C-methyl-4-hydroxyphenylalanine (14C-3-o-methyldopa; 14C-OMD), to rats, 15-20% of the injected radioactivity appeared in the expired air as 14C-CO2 over a period of 3-4 days; 65% of the dose was excreted in the urine and 8% in the faeces. When the experiments were repeated in rats with biliary fistulae, 20% of the dose was excreted in the bile in the first 24 hours, and there was no longer any detectable 14C-CO2 in the expired air. These studies establish that 3-o-methyldopa is demethylated in rats in vivo and that the demethylation occurs mainly in the gut.

AB - Following the intraperitoneal administration of L-3-O-14C-methyl-4-hydroxyphenylalanine (14C-3-o-methyldopa; 14C-OMD), to rats, 15-20% of the injected radioactivity appeared in the expired air as 14C-CO2 over a period of 3-4 days; 65% of the dose was excreted in the urine and 8% in the faeces. When the experiments were repeated in rats with biliary fistulae, 20% of the dose was excreted in the bile in the first 24 hours, and there was no longer any detectable 14C-CO2 in the expired air. These studies establish that 3-o-methyldopa is demethylated in rats in vivo and that the demethylation occurs mainly in the gut.

UR - https://www.scopus.com/pages/publications/49649155672

U2 - 10.1016/0024-3205(71)90294-3

DO - 10.1016/0024-3205(71)90294-3

M3 - Article

AN - SCOPUS:49649155672

SN - 0024-3205

VL - 10

SP - 1243

EP - 1251

JO - Life Sciences

JF - Life Sciences

IS - 21, Part 1

ER -

Demethylation of 3-O-methyldopa in the rat

Abstract

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