Destruction of noradrenergic neurons in rabbit brainstem elevates plasma vasopressin, causing hypertension

W. W. Blessing, A. F. Sved, D. J. Reis

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

When Al noradrenergic neurons in the caudal ventrolateral medulla of rabbits are destroyed electrolytically or by local injection of the neurotoxin kainic acid, the concentration of vasopressin in plasma increases, causing hypertension. The Al neurons may tonically inhibit the activity of vasopressin-secreting neuroendocrine cells through a direct hypothalamic projection.

Original languageEnglish
Pages (from-to)661-663
Number of pages3
JournalScience
Volume217
Issue number4560
DOIs
Publication statusPublished - 13 Aug 1982
Externally publishedYes

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