Destruction of noradrenergic neurons in rabbit brainstem elevates plasma vasopressin, causing hypertension

W. W. Blessing; A. F. Sved; D. J. Reis

doi:10.1126/science.6124043

Destruction of noradrenergic neurons in rabbit brainstem elevates plasma vasopressin, causing hypertension

W. W. Blessing
, A. F. Sved
, D. J. Reis

Research output: Contribution to journal › Article › peer-review

141 Citations (Scopus)

Abstract

When Al noradrenergic neurons in the caudal ventrolateral medulla of rabbits are destroyed electrolytically or by local injection of the neurotoxin kainic acid, the concentration of vasopressin in plasma increases, causing hypertension. The Al neurons may tonically inhibit the activity of vasopressin-secreting neuroendocrine cells through a direct hypothalamic projection.

Original language	English
Pages (from-to)	661-663
Number of pages	3
Journal	Science
Volume	217
Issue number	4560
DOIs	https://doi.org/10.1126/science.6124043
Publication status	Published - 13 Aug 1982
Externally published	Yes

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title = "Destruction of noradrenergic neurons in rabbit brainstem elevates plasma vasopressin, causing hypertension",

abstract = "When Al noradrenergic neurons in the caudal ventrolateral medulla of rabbits are destroyed electrolytically or by local injection of the neurotoxin kainic acid, the concentration of vasopressin in plasma increases, causing hypertension. The Al neurons may tonically inhibit the activity of vasopressin-secreting neuroendocrine cells through a direct hypothalamic projection.",

author = "Blessing, \{W. W.\} and Sved, \{A. F.\} and Reis, \{D. J.\}",

year = "1982",

month = aug,

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doi = "10.1126/science.6124043",

language = "English",

volume = "217",

pages = "661--663",

journal = "Science",

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AU - Blessing, W. W.

AU - Sved, A. F.

AU - Reis, D. J.

PY - 1982/8/13

Y1 - 1982/8/13

N2 - When Al noradrenergic neurons in the caudal ventrolateral medulla of rabbits are destroyed electrolytically or by local injection of the neurotoxin kainic acid, the concentration of vasopressin in plasma increases, causing hypertension. The Al neurons may tonically inhibit the activity of vasopressin-secreting neuroendocrine cells through a direct hypothalamic projection.

AB - When Al noradrenergic neurons in the caudal ventrolateral medulla of rabbits are destroyed electrolytically or by local injection of the neurotoxin kainic acid, the concentration of vasopressin in plasma increases, causing hypertension. The Al neurons may tonically inhibit the activity of vasopressin-secreting neuroendocrine cells through a direct hypothalamic projection.

UR - https://www.scopus.com/pages/publications/0019976870

U2 - 10.1126/science.6124043

DO - 10.1126/science.6124043

M3 - Article

C2 - 6124043

AN - SCOPUS:0019976870

SN - 0036-8075

VL - 217

SP - 661

EP - 663

JO - Science

JF - Science

IS - 4560

ER -

Destruction of noradrenergic neurons in rabbit brainstem elevates plasma vasopressin, causing hypertension

Abstract

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