Detectable anti-proteinase-3 antibodies precede clinical manifestations in a case of anti-neutrophil cytoplasmic antibody-associated vasculitis

A. Y.S. Lee, M. J. Nissen, D. Beroukas, M. J. Ahern, J. A. Barbara

Research output: Contribution to journalLetterpeer-review

4 Citations (Scopus)

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are devastating clinical syndromes characterized by small vessel vasculitis occasioning multiorgan dysfunction, such as renal and pulmonic involvement, and ANCAs. These antibodies are chiefly directed against proteinase-3 (PR3) and myeloperoxidase (MPO) antigens. We describe a rare case of AAV where anti-PR3 antibodies were detected in the serum months before the onset of the clinical syndrome. We also discuss the emerging concept of ‘pre-disease’ status with rheumatic diseases.
Original languageEnglish
Pages (from-to)76-77
Number of pages2
JournalScandinavian Journal of Rheumatology
Volume50
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • antibodies
  • vasculitis
  • neutrophil
  • cytoplasmic

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