Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

Chris Leung, Feng Guo, Yuning Hong, Engui Zhao, Ryan Kwok, Nelson Leung, Sijie Chen, Nishant Vaikath, Omar El-Agnaf, Youhong Tang, Wei-Ping Gai, Ben Tang

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    Abstract

    We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.

    Original languageEnglish
    Pages (from-to)1866-1869
    Number of pages4
    JournalChemical Communications
    Volume51
    Issue number10
    DOIs
    Publication statusPublished - 4 Feb 2015

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  • Cite this

    Leung, C., Guo, F., Hong, Y., Zhao, E., Kwok, R., Leung, N., Chen, S., Vaikath, N., El-Agnaf, O., Tang, Y., Gai, W-P., & Tang, B. (2015). Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence. Chemical Communications, 51(10), 1866-1869. https://doi.org/10.1039/c4cc07911f