Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D

Doan Ngo, Wai Chan, S Rajendrana, Tamila Heresztyn, Anjalee Amarasekera, Aaron Sverdlov, P O'Loughlin, Howard Morris, Yuliy Chirkov, Richard Norman, John Horowitz

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    Abstract

    Background: Polycystic ovary syndrome (PCOS) is associated with incremental risk of atherosclerosis and possibly of cardiovascular events. Insulin resistance (IR) occurs frequently in PCOS subjects, which might be one of the mechanisms involved in engendering such risk. We sought to evaluate whether the impact of other factors potentially associated both with PCOS and with IR might differentially modulate degree of IR in women with and without PCOS. Methods and results: We measured body mass index (BMI), hs-CRP, plasma concentrations of asymmetric dimethylarginine (ADMA), vitamin D (25(OH)D3) levels and platelet responsiveness to nitric oxide donor sodium nitroprusside (NO responsiveness) in 47 young women (n = 27 with PCOS and n = 20 weight-matched controls) without metabolic syndrome, hypertension or overt cardiovascular disease. We performed univariate and multivariate regression analyses to establish correlates of the quantitative insulin-sensitivity check index (QUICKI), as a marker of IR. On univariate analysis, plasma 25(OH)D3 levels and low NO responsiveness tended to be direct correlates with QUICKI in the entire subject group. BMI, hs-CRP, and ADMA levels were significant inverse correlates of QUICKI in PCOS subjects, but not in subjects without PCOS. On multivariate analysis, NO responsiveness, and 25(OH)D3 levels, but not PCOS per se were significant correlates of QUICKI. Conclusions: In the entire cohort of young women, low NO responsiveness and vitamin D deficiency are associated with low QUICKI, while elevated ADMA, inflammatory activation and obesity are selectively associated with low QUICKI in PCOS subjects; this may contribute to the increased cardiovascular risk associated with this syndrome.

    Original languageEnglish
    Pages (from-to)326-330
    Number of pages5
    JournalNITRIC OXIDE-BIOLOGY AND CHEMISTRY
    Volume25
    Issue number3
    DOIs
    Publication statusPublished - 30 Oct 2011

    Keywords

    • Asymmetric dimethylarginine
    • Insulin resistance
    • Obesity
    • Polycystic ovary syndrome
    • Vitamin D
    • Women health

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    Ngo, D., Chan, W., Rajendrana, S., Heresztyn, T., Amarasekera, A., Sverdlov, A., O'Loughlin, P., Morris, H., Chirkov, Y., Norman, R., & Horowitz, J. (2011). Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 25(3), 326-330. https://doi.org/10.1016/j.niox.2011.06.005