Determination of time constants in kinetic studies involving radiolabeled tracer molecules

M. E. Jones, T. E. Nicholas, J. H.T. Power, H. A. Barr

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    In tracer kinetic studies, two homogeneous well-mixed compartments may be related as precursor and product. The time constant for the product compartment can then be estimated from the two specific activity vs. time curves. We examine ten methods of estimating this time constant for data with several different error patterns, and conclude that the present practice of transforming the data to a straight line yields an inefficient but unbiased estimate of the time constant. A least squares estimate, appropriately weighted and taking into account that both precursor and product specific activities are subject to error is expected theoretically and found in practice, to be most efficient. It is however, mathematically complicated. A modified approach using a minimum χ2 estimate in which precursor specific activities are treated as error-free, is almost as efficient. It is mathematically simple, and outperforms the currently used estimators.

    Original languageEnglish
    Pages (from-to)235-247
    Number of pages13
    JournalInternational Journal of Bio-Medical Computing
    Volume19
    Issue number3-4
    DOIs
    Publication statusPublished - Nov 1986

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