Development and validation of a short food frequency questionnaire to measure dietary intake of a selection of immune-modulating nutrients in patients with established peripheral arterial disease

Bianca J. Collins, Christopher L. Delaney, Jade E. Boffo, Michelle D. Miller

Research output: Contribution to journalArticlepeer-review

Abstract

Nutrients with the ability to modulate the immune system (immune-modulating nutrients; IMN) may help prevent the development and progression of atherosclerosis, the main disease process underlying peripheral artery disease (PAD). Currently, no screening tool exists to measure IMN intake; therefore, the aim of this project is to develop and validate a short food frequency questionnaire (FFQ) that measures dietary intake of 14 nutrients with proposed immune-modulating effects, identified by the literature (copper, iron and zinc, vitamins A, C, D and E, alpha linolenic acid, total long-chain omega-3 fatty acids, arginine, glutamic acid, isoleucine, leucine and valine) in patients with established PAD. A 21-item FFQ was developed to measure average daily intake of IMNs over the past 12 months. Participants (n = 106) were recruited from Flinders Medical Centre, where they completed the FFQ followed by the reference method, a diet history reflecting usual intake over the past week. The mean age of participants was 72 years, with 83% being male (n = 88). Bland–Altman analysis resulted in a statistically non-significant p-value (p-value > 0.05) for 12 out of 14 nutrients, demonstrating good agreement between the two methods. Additionally, over 50% of nutrients had a sensitivity or specificity >70%. Consequently, the novel 21-item FFQ was determined to be a promising measure of dietary intake of 14 IMNs in patients with PAD when compared to the reference method of a diet history, and it is recommended that further investigations of the utility against biomarkers be explored in the future.

Original languageEnglish
Article number3316
Number of pages15
JournalNutrients
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Atherosclerosis
  • Dietary intake
  • Food frequency questionnaire
  • Peripheral arterial disease

Fingerprint

Dive into the research topics of 'Development and validation of a short food frequency questionnaire to measure dietary intake of a selection of immune-modulating nutrients in patients with established peripheral arterial disease'. Together they form a unique fingerprint.

Cite this