Development of the immune system in the human embryo

Zakir Hossain; AHM Mohsinul Reza; Wafaa A Qasem; James K Friel; Abdelwahab Omri

doi:10.1038/s41390-022-01940-0

Development of the immune system in the human embryo

Zakir Hossain, AHM Mohsinul Reza, Wafaa A Qasem, James K Friel, Abdelwahab Omri

College of Science and Engineering

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

The fetal immune system is highly specialized which is to generate both tolerogenic and protective immune responses to tolerate both self- and maternal-antigens. Fetal T cells with pro-inflammatory potential are born in a tolerogenic environment and are tightly controlled by both cell-intrinsic and -extrinsic mechanisms. Fetal B-1 and B-2 B cells involved in innate and adaptive immune responses, respectively, arise in staggered waves of development from distinct progenitors. Innate immune responses are the key to the protection against infection and adaptive immunity creates memory after an initial response to a specific pathogen. This review aims to discuss the recent advances in understanding the development of immune system in fetus.

Impact

During gestation, essential developmental changes occur to survive the neonates.

At early stage, developmental signals and changes may be influenced due to immune deficiencies.

Original language	English
Pages (from-to)	951-955
Number of pages	5
Journal	Pediatric Research
Volume	92
Issue number	4
Early online date	18 Jan 2022
DOIs	https://doi.org/10.1038/s41390-022-01940-0
Publication status	Published - Oct 2022

Keywords

Immune system
Foetus
Immune response
Maternal antigens
T cells
Embryo

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Development of the immune system in the human embryo

Abstract

Keywords

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