Developmental loss of a smooth muscle muscarinic receptor population

M. F. Crouch, C. P. Morris, T. B. Cheah, R. A. Rush

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    The radioligand [3H]quinuclidinyl benzilate has been used to examine the muscarinic receptor population of the chick expansor secundariorum muscle during its post-hatch development. At hatch the muscle bound 0.165 fmol of the ligand, but during the following two weeks binding decreased rapidly. Further reduction in ligand binding to the adult stage was observed, but at a much slower rate. The developmental loss of binding sites within this tissue corresponds to previously demonstrated reduction in acetylcholine sensitivity.

    Original languageEnglish
    Pages (from-to)212-215
    Number of pages4
    JournalBrain Research
    Volume232
    Issue number1
    DOIs
    Publication statusPublished - 28 Jan 1982

    Keywords

    • chicken
    • quinuclidinyl benzilate
    • radioligand
    • sympathetic nerves

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