Developmental validation of 15 X chromosomal short tandem repeat markers

Toni Diegoli, Adrian Linacre, Michael Coble

    Research output: Contribution to conferencePaperpeer-review

    Abstract

    The use of X chromosomal short tandem repeat (STR) markers has been greatly increasing in the forensic setting. Using guidelines set forth previously for the validation of autosomal and Y STRs, aspects of the feasibility of routine X chromosomal STR use were evaluated. Two mini-X chromosomal STR multiplexes capable of amplifying 15 total markers were developed and utilized to determine allele nomenclature, allele/genotype frequencies, mutation rates, and linkage between markers. Additionally, a concordance study between these multiplexes and a commercially available kit was performed. Here, the authors present an overview of this extensive developmental validation study.

    Original languageEnglish
    Pagese142-e143
    DOIs
    Publication statusPublished - 30 Oct 2013
    Event25th Congress of the International Society for Forensic Genetics -
    Duration: 2 Sep 2013 → …

    Conference

    Conference25th Congress of the International Society for Forensic Genetics
    Period2/09/13 → …

    Keywords

    • Linkage
    • Multiplex development
    • Mutation rate
    • Population database
    • Short tandem repeat
    • X chromosome

    Fingerprint Dive into the research topics of 'Developmental validation of 15 X chromosomal short tandem repeat markers'. Together they form a unique fingerprint.

    Cite this