Developmental validation of 15 X chromosomal short tandem repeat markers

Toni Diegoli, Adrian Linacre, Michael Coble

    Research output: Contribution to conferencePaperpeer-review

    1 Citation (Scopus)

    Abstract

    The use of X chromosomal short tandem repeat (STR) markers has been greatly increasing in the forensic setting. Using guidelines set forth previously for the validation of autosomal and Y STRs, aspects of the feasibility of routine X chromosomal STR use were evaluated. Two mini-X chromosomal STR multiplexes capable of amplifying 15 total markers were developed and utilized to determine allele nomenclature, allele/genotype frequencies, mutation rates, and linkage between markers. Additionally, a concordance study between these multiplexes and a commercially available kit was performed. Here, the authors present an overview of this extensive developmental validation study.

    Original languageEnglish
    Pagese142-e143
    DOIs
    Publication statusPublished - 30 Oct 2013
    Event25th World Congress of the International Society for Forensic Genetics - Melbourne, Australia
    Duration: 2 Sept 20137 Sept 2013
    Conference number: 25

    Conference

    Conference25th World Congress of the International Society for Forensic Genetics
    Abbreviated titleISFG 2013
    Country/TerritoryAustralia
    CityMelbourne
    Period2/09/137/09/13

    Keywords

    • Linkage
    • Multiplex development
    • Mutation rate
    • Population database
    • Short tandem repeat
    • X chromosome

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